4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:分子类,蛋白类,抗体类,生化类试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > 微孔/IHCR1013-6 |抗钙结合蛋白D-28K抗体,预稀释/IHCR1013-6/6毫升
商品详细微孔/IHCR1013-6 |抗钙结合蛋白D-28K抗体,预稀释/IHCR1013-6/6毫升
微孔/IHCR1013-6 |抗钙结合蛋白D-28K抗体,预稀释/IHCR1013-6/6毫升
微孔/IHCR1013-6 |抗钙结合蛋白D-28K抗体,预稀释/IHCR1013-6/6毫升
商品编号: IHCR1013-6
品牌: 密理博
市场价: ¥5340.00
美元价: 3204.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
Catalogue NumberIHCR1013-6
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Calbindin D-28K Antibody, prediluted
Background InformationCalbindin D28k is a member of a large family of intracellular calcium-binding proteins of the EF-hand related to calmodulin and troponin-C. The biological roles of Calbindin D28k include, calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to several disease states. Decline in calbindin D28k in hippocampal dentate granule cells correlates with the kindling model for epilepsy. Calbindin D28k immunoreactivity is specifically absent from neuronal poplulations lost early in ALS, while substantial loss of neurons which do contain the protein occur in patients with Huntington's disease.
Product Information
FormatPurified
PresentationLiquid diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as preservative.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8oC. Refer to vial for expiration dating.
Applications
ApplicationDetect Calbindin D-28K using this Anti-Calbindin D-28K Antibody, prediluted validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesAntibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.

Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.

Incubation: 30 minutes with IHC Select® Detection Kits.

Calbindin has been prediluted for use as the primary antibody with Chemicon's IHC Select® Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used. For optimized protocol details, visit www.chemicon.com and select the protocols link under Cat. No.IHCR1013-6.
Biological Information
ImmunogenPurified recombinant calbindin.
HostRabbit
SpecificityCalbindin. Shows no cross-reactivity to calretinin by Western blot. The antibody produces specific staining of cerebellum Purkinje cells, molecular layer dendrites and axonal fibers, stains cell bodies and fibers in neuronal subpopulations.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCalbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted.
Gene Symbol
  • CALB1
  • D-28K
  • CALB
  • CAB27
  • Calbindin
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05937 # Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
SIZE: 261 amino acids; 30025 Da
SUBUNIT: Interacts with RANBP9.
DOMAIN: SwissProt: P05937 This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.
SIMILARITY: Belongs to the calbindin family. & Contains 5 EF-hand domains.
Physicochemical Information
Dimensions
Materials Information
Materials Information
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。