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微孔/FCCS025210 | Flowcell等™ PI3K mTOR信号级联套件/FCCS025210/25测试和#47；配套元件
微孔/FCCS025210 | Flowcell等™ PI3K mTOR信号级联套件/FCCS025210/25测试和#47；配套元件
商品编号：
FCCS025210
品牌：
密理博
市场价：
¥0.00
美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | FCCS025210 |
| TradeName |
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| Description | FlowCellect™PI3K-mTORSignalingCascadekit |
| Overview | SignalingthroughthePI3K/Akt/mTORpathwayisconstitutivelyactiveinmanycancercellsduetothelossofPTEN(tumorsuppressor),exposuretocarcinogens,activationofgrowthreceptors,aswellasmutationsoramplificationsofPI3KorAkt.Therelevanceofthispathwayindifficulttotreatcancersmakesthesessignalingnodesprimetargetsinadvancinganticancertherapies. Millipore’sFlowCellect™PI3K-mTORAnalysisKitincludestwodirectlyconjugatedphospho-specificsignalingantibodieswhichareoptimizedformulti-colorflowcytometryapplicationstoanalyzethemTORpathwayingreatdetail.ThephosphorylationofAktisindicativeoftheupstreamPI3Ksignaling,markingthecellsinitiationintoproliferationorcellsurvival.Phosporylated-RibosomalS6proteinisindicativeofdownstreammTORandp70S6KsignalingleADIngtoproteintranslation. Byprovidingbothoftheseantibodiesinonekit,theresearcherhasthecompletesolutionwhenexaminingthemTORpathwaywhichisbeneficialfortheelucidationofdrugeffectivenessintheircancerresearch. |
| AlternateNames |
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| BackgroundInformation | Examinationofcellsignalingpathwaysandmonitoringtheiractivationstatushavebeenextremelyimportantforresearcherstounderstandthedetailedmechanismsofcellularfunctionsandthecauseofvariousdiseases.Manysignaltransductionpathwayshavebeenimplicatedtoleadtomultipleoutcomessuchasapoptosis,celldifferentiation,cellgrowthandcellproliferation,allofwhichhavebeenextensivelystudiedforthetreatmentofvariouscancersandautoimmunediseases. Thestudyofcellsignalingpathwaysarenowmadeeasierwiththeuseofactivationstatus-specificandphospho-specificantibodies.Measurementofproteinphosphorylationwithphospho-specificantibodieshasgiveninsightintokinasesignalingcascades[Krutzik,P.O.etal.(2003].Multi-parameterphosphoflowcytometryisapowerfultoolforstudyingmultiplepathwaysinamixedcellpopulationatthesametime. Milliporeoffersarangeofnovelantibodybasedmulti-parameterFlowCellect™kitswhicharespecificallydesignedtoaddressthecurrentneedsinphosphoflowcytometryanalysisofcellsignalingpathwaysandcancerresearchinamulti-parametricfashion.Alloftheantibodiesprovidedinthekithavebeendirectlyconjugatedandoptimizedformulti-colorflowcytometryapplications.Byusingacombinationofantibodiesprovidedinthekit,researcherscannowaccuratelymeasurekeysignalingnodesandendpointsactivations.Moreover,researcherscanalsodissectanyparticularlinearsignalingpathwaycascadebymeasuringtheactivationofseveralcomponentsinatimecoursedependentmanner.ByusingtheFlowCellect™PI3K-mTORSignalingCascadekit,theresearchercannowstudymTORingreaterdetailanditsrelationshipingeneralcellfunctionsuchascellproliferation,apoptosisandcancer. AllFlowCellect™kitsareoptimizedonthebench-topGuava®flowcytometrysystems,whichsavesvaluabletimeandsamplevolume.Allkitscontainoptimizedfixation,permeABIlization,washandflowbufferstoprovideresearcherswithacompletesolutionforsimultaneousdetectionofmultiplepathwayactivations.WiththeGuavaplatformandFlowCellect™kits,onecanfinallyhaveaneasy,reliableandfullyvalidatedsolutiontostudythecomplexcellsignalingpathwaysrightinthecomfortofyourownlab. |
| ProductInformation | |
|---|---|
| Components |
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| Detectionmethod | 125IFluorescent |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 4-8°Cforantibodiesandbuffers |
| BIOLOGicalInformation | |
|---|---|
| Host | Rabbit/Murine |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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