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Millipore/05-802R | Anti-phospho-Akt (Thr308) Antibody, clone 50-1C-25, rabbit monoclonal/05-802R/100 µL
Millipore/05-802R | Anti-phospho-Akt (Thr308) Antibody, clone 50-1C-25, rabbit monoclonal/05-802R/100 µL
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-802R |
| Replaces | 05-802 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-phospho-Akt(Thr308)Antibody,clone50-1C-25,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Akt/PKBisaSer/ThrkinaseandamajorknowneffecterofthePI3Kinasepathway.ItisinvolvedinmultiplesignalingpathwaysthatrelatetomanyBIOLOGicalprocessesincludingmetabolism,apoptosis,cellcyclecontrol,angiogenesis,differentiation,andcellgrowthandproliferation.Inmammals,threeisoformsofAkt(Akt1/PKCα,Akt2/PKBβ,andAkt3/PKBγ)exists.Theyexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Akt1isthepredominantisoformthatisinmosttissuesandisthoughttohaveadominantroleingrowth,survival,embryonicdevelopment,andADIpocytedifferentiation.Akt2iscorrelatedwiththeregulationofglucosehomeostasisandisthepredominantisoformexpressedininsulin-responsivetissues.Akt3isabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalPleckstrinHomology(PH)domainthatprovidesalipid-bindingmodule,acentralcatalyticdomaincontainingThr308,andaC-terminalhydrophobicmotifcontainingSer473.TheactivationofAKTisdependentonadualregulatorymechanismthatrequiresbothitstranslocationtotheplasmamembraneanddualphosphorylationonThr308andSer473byPDK1andtheTORC2complex,respectively. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | ProteinApurifiedrecombinantrabbitmonoclonalsupernatantin0.1MTris-Glycine(pH7.4)150mMNaCl,and0.05%NaN3with40%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | Detectphospho-Akt(Thr308)usingthisAnti-phospho-Akt(Thr308)Antibody,clone50-1C-25validatedforuseinWB,IF,IC,ELISA. |
| KeyApplications |
|
| ApplicationNotes | WesternBlotAnalysis: ThislotdetectedAktwhenphosphorylatedonThr308at1:1,000dilutioninPDGF-treatedNIH/3T3lysatesviaSDS-PAGEandtransferredtoPVDF(Immobilon-P). |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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