4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:分子类,蛋白类,抗体类,生化类试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > 密理博/MAB3706 |抗CD4抗体,细胞内,克隆024-10D6.B3/MAB3706/100µ;G
商品详细密理博/MAB3706 |抗CD4抗体,细胞内,克隆024-10D6.B3/MAB3706/100µ;G
密理博/MAB3706 |抗CD4抗体,细胞内,克隆024-10D6.B3/MAB3706/100µ;G
密理博/MAB3706 |抗CD4抗体,细胞内,克隆024-10D6.B3/MAB3706/100µ;G
商品编号: MAB3706
品牌: 密理博
市场价: ¥5540.00
美元价: 3324.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMAB3706
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-CD4Antibody,intracellular,clone024-10D6.B3
ProductInformation
FormatPurified
PresentationPurifiedimmunoglobulin.Liquidin0.02Mphosphatebuffer,0.25MNaCl,with0.1%sodiumazide.
StorageandShippingInformation
StorageConditionsMaintainat2-8°Cforupto12monthsfromdateofreceipt.
Applications
ApplicationDetectCD4usingthisAnti-CD4Antibody,intracellular,clone024-10D6.B3validatedforuseinELISA,EMSA,FUNC&IC.
KeyApplications
  • ELISA
  • ElectrophoreticMobilityShiftAssay
  • AffectsFunction
  • Immunocytochemistry
ApplicationNotesImmunocytochemistry

ELISA

Stimulation/InhibitionofBIOLOGicalactivity

Electrophoreticmobilityshiftanalysis

Optimalworkingdilutionsmustbedeterminedbyenduser.
BiologicalInformation
ImmunogenSyntheticpeptidecorrespondingtoaminoacids439-458ofthecytoplasmictailofhumanCD4.
Epitopeintracellular
Clone024-10D6.B3
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityRecognizesthecytoplasmictailofCD4.Manyfunctionshavebeenassignedtothistail,includinganti-viralregulation(down/upregulationofCD4),T-cellmaturation,activationanddifferentiation,andLcksignaltransduction,amongothers.ThisantibodyisusefulasacontrolforstudiesinvolvingtargetingofintracellularproteindomainsofTcells.
IsotypeIgG1
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • CD4
  • CD4mut
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P01730#AccessoryproteinforMHCclass-IIantigen/T-cellreceptorinteraction.MayregulateT-cellactivation.Inducestheaggregationoflipidrafts.
SIZE:458aminoacids;51111Da
SUBUNIT:AssociateswithLCK.BindstoHIV-1gp120andtoP4HB/PDIanduponHIV-1bindingtothecellmembrane,ispartofP4HB/PDI-CD4-CXCR4-gp120complex.InteractswithHIV-1Envelopepolyproteingp160andproteinVpu.
SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Localizestolipidrafts.RemovedfromplasmamembranebyHIV-1Nefproteinthatincreasesclathrin-dependentendocytosisofthisantigentotargetittolysosomaldegradation.Cellsurfaceexpressionisalsodown-modulatedbyHIV-1Envelopepolyproteingp160thatinteractswith,andsequestersCD4intheendoplasmicreticulum.
PTM:PalmitoylationandassociationwithLCKcontributetotheenrichmentofCD4inlipidrafts.
SIMILARITY:SwissProt:P01730##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain.
MISCELLANEOUS:PrimaryreceptorforHIV-1.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。