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当前位置: 首页 > 产品中心 > Functional_antibody > 密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL
商品详细密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL
密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL
密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL
商品编号: IHCR2110-6
品牌: 密理博
市场价: ¥5540.00
美元价: 3324.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberIHCR2110-6
TradeName
  • IHCSelect
  • Chemicon
DescriptionIHCSelect®Anti-CD4Antibody,prediluted,clone4B12
ProductInformation
FormatPurified
PresentationLiquiddilutedinPBS,pH7.2withstABIlizers,0.2%Tween20,and0.1%ProClin300aspreservative.
StorageandShippingInformation
StorageConditionsMaintainat2-8°C.Refertovialforexpirationdating.
Applications
ApplicationThisIHCSelectAnti-CD4Antibody,prediluted,clone4B12isvalidatedforuseinIH(P)forthedetectionofCD4.
KeyApplications
  • Immunohistochemistry(Paraffin)
ApplicationNotesAntibodyispredilutedandreadytouseforImmunohistochemistryofformalin-fixed,paraffin-embeddedtissues.

Pretreatment:HeatInducedEpitopeRetrieval(HIER).RecommendEDTA,pH8.0(Cat.No.21546).NosignalwasdetectedwithoutEpitoperetrieval.

Incubation:10minuteswithIHCSelect®DetectionKits.

CD4hasbeenpredilutedforuseastheprimaryantibodywithChemicon"sIHCSelect®DetectionKitsandProtocols(CatalogNos.DAB050,DET-HP1000,APR050,andDET-APR1000),butothersupplier"sIHCdetectionsystemsmaybeused.Foroptimizedprotocoldetails,visitwww.chemicon.comandselecttheprotocolslinkunderCat.No.IHCR2110-6.
BIOLOGicalInformation
ImmunogenProkaryoticrecombinantproteincorrespondingtotheexternaldomainoftheCD4molecule/Mousemyeloma.
Clone4B12
HostMouse
SpecificityTheCD4molecule(T4)isasinglechaintransmembraneglycoproteinwithamolecularweightof59kDa.TheCD4antigenisfoundonaTcellsubsetknownashelper/inducerrepresenting45%ofperipheralbloodlymphocytes.Itisalsopresenton80%ofthymocytes,andatalowerlevelonmonocytes.CD4isexpressedinthemajorityofT-celllymphomas,includingmycosisfungoides.HTLV-1associatedadultTcellleukemia/lymphomaisalsogenerallyCD4positive.AtypicallymphomaCD4panelincludesCD3,CD5,CD8,CD7andTIA-1.
IsotypeIgG1κ
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • CD4
  • CD4mut
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P01730#AccessoryproteinforMHCclass-IIantigen/T-cellreceptorinteraction.MayregulateT-cellactivation.Inducestheaggregationoflipidrafts.
SIZE:458aminoacids;51111Da
SUBUNIT:AssociateswithLCK.BindstoHIV-1gp120andtoP4HB/PDIanduponHIV-1bindingtothecellmembrane,ispartofP4HB/PDI-CD4-CXCR4-gp120complex.InteractswithHIV-1Envelopepolyproteingp160andproteinVpu.
SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Localizestolipidrafts.RemovedfromplasmamembranebyHIV-1Nefproteinthatincreasesclathrin-dependentendocytosisofthisantigentotargetittolysosomaldegradation.Cellsurfaceexpressionisalsodown-modulatedbyHIV-1Envelopepolyproteingp160thatinteractswith,andsequestersCD4intheendoplasmicreticulum.
PTM:PalmitoylationandassociationwithLCKcontributetotheenrichmentofCD4inlipidrafts.
SIMILARITY:SwissProt:P01730##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain.
MISCELLANEOUS:PrimaryreceptorforHIV-1.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。