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密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL

密理博/IHCR2110-6 | IHC Select®抗CD4抗体,预稀释,克隆4B12/IHCR2110-6/6 mL
商品编号:
IHCR2110-6
品牌:
密理博
市场价:
¥5540.00
美元价:
3324.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | IHCR2110-6 |
TradeName |
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Description | IHCSelect®Anti-CD4Antibody,prediluted,clone4B12 |
ProductInformation | |
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Format | Purified |
Presentation | LiquiddilutedinPBS,pH7.2withstABIlizers,0.2%Tween20,and0.1%ProClin300aspreservative. |
StorageandShippingInformation | |
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StorageConditions | Maintainat2-8°C.Refertovialforexpirationdating. |
BIOLOGicalInformation | |
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Immunogen | ProkaryoticrecombinantproteincorrespondingtotheexternaldomainoftheCD4molecule/Mousemyeloma. |
Clone | 4B12 |
Host | Mouse |
Specificity | TheCD4molecule(T4)isasinglechaintransmembraneglycoproteinwithamolecularweightof59kDa.TheCD4antigenisfoundonaTcellsubsetknownashelper/inducerrepresenting45%ofperipheralbloodlymphocytes.Itisalsopresenton80%ofthymocytes,andatalowerlevelonmonocytes.CD4isexpressedinthemajorityofT-celllymphomas,includingmycosisfungoides.HTLV-1associatedadultTcellleukemia/lymphomaisalsogenerallyCD4positive.AtypicallymphomaCD4panelincludesCD3,CD5,CD8,CD7andTIA-1. |
Isotype | IgG1κ |
SpeciesReactivity |
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AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P01730#AccessoryproteinforMHCclass-IIantigen/T-cellreceptorinteraction.MayregulateT-cellactivation.Inducestheaggregationoflipidrafts. SIZE:458aminoacids;51111Da SUBUNIT:AssociateswithLCK.BindstoHIV-1gp120andtoP4HB/PDIanduponHIV-1bindingtothecellmembrane,ispartofP4HB/PDI-CD4-CXCR4-gp120complex.InteractswithHIV-1Envelopepolyproteingp160andproteinVpu. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Localizestolipidrafts.RemovedfromplasmamembranebyHIV-1Nefproteinthatincreasesclathrin-dependentendocytosisofthisantigentotargetittolysosomaldegradation.Cellsurfaceexpressionisalsodown-modulatedbyHIV-1Envelopepolyproteingp160thatinteractswith,andsequestersCD4intheendoplasmicreticulum. PTM:PalmitoylationandassociationwithLCKcontributetotheenrichmentofCD4inlipidrafts. SIMILARITY:SwissProt:P01730##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain. MISCELLANEOUS:PrimaryreceptorforHIV-1. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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