Millipore/MAB5384 |抗NG2硫酸软骨素蛋白多糖抗体/MAB5384/100µ；G
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5384 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-NG2ChondroitinSulfateProteoglycanAntibody |
| BackgroundInformation | NG2isahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Liquidin0.02MPhosphatebuffer,containing0.25MNaCland0.1%azide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearatfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-NG2ChondroitinSulfateProteoglycanAntibodydetectslevelofNG2ChondroitinSulfateProteoglycan&hasbeenpublished&validatedforuseinWB,IC,ELISA,IH. |
| KeyApplications |
|
| ApplicationNotes | Immunocytochemistry:1:200-1:500dilutionofapreviouslotwasusedonoligodendrocyteprecursorcells. ELISA(direct):ApreviouslotofthisantibodywasusedinELISA. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | CelllineexpressingatruncatedformofNG2. |
| Clone | 132.39 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | NG2ChondroitinSulfateProteoglycan.MAB5384reactswithnative,recombinantandproteinfromcellswhichexpressNG2. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Rat.Expectedtoreactwithhumanandmousebasedonsequencesimilarity. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | extracellularmatrixproteinsecretedbymanycelltypes;memberofthelargechondroitinsulfateproteoglycan(CSPG)family;maybeinvolvedwithangiogenesis-dependentprocessessuchaswoundhealingortumorgrowth[RGD] |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsABIlitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreADIngbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades. SIZE:2326aminoacids;251909Da SUBUNIT:InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16(Bysimilarity).InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein;Extracellularside.Apicalcellmembrane;Single-passtypeImembraneprotein;Extracellularside.Cellprojection›lamellipodiummembrane;Single-passtypeImembraneprotein;Extracellularside.Note=Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Afractionmayundergocellsurfaceproteolysisandsecretion. TISSUESPECIFICITY:Neuralcellsandalsoextraneuraltissues,especiallyinthedevelopingmesenchyme. PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation.InvolvedininteractionwithMMP16andITGA4.PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility. MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells. |
| MolecularWeight | ~280kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
