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Millipore/MAB5284 |抗硫酸软骨素蛋白多糖抗体，脑（核心蛋白），克隆Cat-301/MAB5284/100&mic
Millipore/MAB5284 |抗硫酸软骨素蛋白多糖抗体，脑（核心蛋白），克隆Cat-301/MAB5284/100&mic
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5284 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-ChondroitinSulfateProteoglycanAntibody,Brain(coreprotein),cloneCat-301 |
| AlternateNames |
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| BackgroundInformation | Theantigenrecognizedbythisclone,CAT-301isaproteoglycanthatisdevelopmentalyregulated,highmolecularchondroitinsulphateproteoglycanfoundontheextracellularsurfaceofmammalianneurons.ItisexpressedlateindevelopmentandalthoughnodefinitiverolehasbeenidentifiedforCAT-301,itisbelievedtohavearoleinthestABIlisationofsynapticstructure. Thenamederivesfromthenameofthemonoclonalantibodyoriginallyusedtoidentifiedbyitsexpression,whichwasdetectedimmunocytochemicaly DisruptionofthenormalpatternsofneuronalactivityduringthecriticalearlypostnatalperiodbyphysicalorbiochemicalmeansresultsinalargeandirreversIBLereductioninlevelsofCAT-301.Similarinterventioninmatureanimalshasnoeffect CAT-301isrelatedtoaggrecanfromarticularcartilage.TheCAT-301antibodyimmunoreactswithaggrecan,andthechondroitinasetreatedaggrecanandCAT-301bothhaveapparentsizesof550kDa.HoweverCAT-301isnotglycosylatedbykeratansulphate,asaggrecanis. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Purifiedimmunoglobulin.Liquid.Buffer=0.02MPhosphatebuffer,0.25MNaCl,pH7.6with0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsforupto6months. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Felinespinalcordfixedgraymatter. |
| Epitope | Brain(coreprotein) |
| Clone | Cat-301 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Chondroitinsulfateproteoglycan(CSPG),braincoreprotein. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisamemberoftheaggrecan/versicanproteoglycanfamily.Theencodedproteinisanintegralpartoftheextracellularmatrixincartilagenoustissueanditwithstandscompressionincartilage.Mutationsinthisgenemaybeinvolvedinskeletaldysplasiaandspinaldegeneration.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentproteinisoformshavebeenobservedinthisgene. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16112#Thisproteoglycanisamajorcomponentofextracellularmatrixofcartilagenoustissues.Amajorfunctionofthisproteinistoresistcompressionincartilage.ItbindsavidlytohyaluronicacidviaanN-terminalglobularregion. SIZE:2415aminoacids;250193Da SUBUNIT:InteractswithFBLN1(Bysimilarity). SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix(Bysimilarity). TISSUESPECIFICITY:Restrictedtocartilages. DEVELOPMENTALSTAGE:Expressionwasdetectedinchondrocytesthroughoutthedevelopingskeleton. DOMAIN:SwissProt:P16112Twoglobulardomains,G1andG2,comprisetheN-terminusoftheproteoglycan,whileanotherglobularregion,G3,makesuptheC-terminus.G1containsLinkdomainsandthusconsistsofthreedisulfide-bondedloopstructuresdesignatedastheA,B,B"motifs.G2issimilartoG1.Thekeratansulfate(KS)andthechondroitinsulfate(CS)attachmentdomainsliebetweenG2andG3. PTM:Containsmostlychondroitinsulfate,butalsokeratansulfatechains,N-linkedandO-linkedoligosaccharides.Thereleaseofaggrecanfragmentsfromarticularcartilageintothesynovialfluidatallstagesofhumanosteoarthritisistheresultofcleavagebyaggrecanase. DISEASE:SwissProt:P16112#DefectsinAGC1arethecauseofspondyloepiphysealdysplasiatypeKimberley(SEDK)[MIM:608361].Spondyloepiphysealdysplasiasareaheterogeneousgroupofcongenitalchondrodysplasiasthatspecificallyaffectepiphysesandvertebrae.TheautosomaldominantSEDKisassociatedwithprematuredegenerativearthropathy. SIMILARITY:Belongstotheaggrecan/versicanproteoglycanfamily.&Contains1C-typelectindomain.&Contains1EGF-likedomain.&Contains1Ig-likeV-type(immunoglobulin-like)domain.&Contains4Linkdomains.&Contains1Sushi(CCP/SCR)domain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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