Millipore/MAB2035 |抗硫酸软骨素6抗体，克隆MK-302/MAB2035/100µ；L
市场价：
¥5340.00
美元价：
3204.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB2035 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Chondroitin6SulfateAntibody,cloneMK-302 |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Presentation | Ascitesliquid;nopreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | Anti-Chondroitin6SulfateAntibody,cloneMK-302isanantibodyagainstChondroitin6SulfateforuseinELISA,RIA&WB. |
| KeyApplications |
|
| ApplicationNotes | ELISAat1:100-1:5,000 RIAat1:100-1:200. ChondroitinaseABCdigestionpriortoantibodyreactionisrequiredforantibodyreactivity.{0.5U/mLin100mMTris-HCL,30minutesroomtemperature}Adramaticproteolyticdigestionofthecoreprotein(e.g.withpapainorpronase)significantlyreducestheantibodyreactivity. Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | ChondroitinaseABC-digestedadulthumanaggrecan. |
| Clone | MK-302 |
| Host | Mouse |
| Specificity | Reactswithawiderangeofcartilageproteoglycansaftereitherchondroitinase(ABCorAC)ortesticularhyaluronidasedigestion.NativeproteoglycansdonotreactwithMAB2035.Antibodybindingtoepitopeissuccessfullyinhibitedbydisaccharidesofchondroitin-6-sulfate.Recognizesthechondroitin-6-sulfatestubs(preferentiallyinclusters)ofhighdensitycartilageproteoglycansofdifferentspecies.Nocross-reactivitywithdermatansulfate,keratansulfateorchondroitin-4-sulfate. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisamemberoftheaggrecan/versicanproteoglycanfamily.Theencodedproteinisanintegralpartoftheextracellularmatrixincartilagenoustissueanditwithstandscompressionincartilage.Mutationsinthisgenemaybeinvolvedinskeletaldysplasiaandspinaldegeneration.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentproteinisoformshavebeenobservedinthisgene. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16112#Thisproteoglycanisamajorcomponentofextracellularmatrixofcartilagenoustissues.Amajorfunctionofthisproteinistoresistcompressionincartilage.ItbindsavidlytohyaluronicacidviaanN-terminalglobularregion. SIZE:2415aminoacids;250193Da SUBUNIT:InteractswithFBLN1(Bysimilarity). SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix(Bysimilarity). TISSUESPECIFICITY:Restrictedtocartilages. DEVELOPMENTALSTAGE:Expressionwasdetectedinchondrocytesthroughoutthedevelopingskeleton. DOMAIN:SwissProt:P16112Twoglobulardomains,G1andG2,comprisetheN-terminusoftheproteoglycan,whileanotherglobularregion,G3,makesuptheC-terminus.G1containsLinkdomainsandthusconsistsofthreedisulfide-bondedloopstructuresdesignatedastheA,B,B"motifs.G2issimilartoG1.Thekeratansulfate(KS)andthechondroitinsulfate(CS)attachmentdomainsliebetweenG2andG3. PTM:Containsmostlychondroitinsulfate,butalsokeratansulfatechains,N-linkedandO-linkedoligosaccharides.Thereleaseofaggrecanfragmentsfromarticularcartilageintothesynovialfluidatallstagesofhumanosteoarthritisistheresultofcleavagebyaggrecanase. DISEASE:SwissProt:P16112#DefectsinAGC1arethecauseofspondyloepiphysealdysplasiatypeKimberley(SEDK)[MIM:608361].Spondyloepiphysealdysplasiasareaheterogeneousgroupofcongenitalchondrodysplasiasthatspecificallyaffectepiphysesandvertebrae.TheautosomaldominantSEDKisassociatedwithprematuredegenerativearthropathy. SIMILARITY:Belongstotheaggrecan/versicanproteoglycanfamily.&Contains1C-typelectindomain.&Contains1EGF-likedomain.&Contains1Ig-likeV-type(immunoglobulin-like)domain.&Contains4Linkdomains.&Contains1Sushi(CCP/SCR)domain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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