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Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg
Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg
市场价:
¥6780.00
美元价:
4068.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | MAB2029 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27 |
ProductInformation | |
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Format | Purified |
Presentation | PurifiedfromascitesbyProteinASepharose™chromatography.Purifiedimmunoglobulinin0.02MPBSpH7.6,0.25MNaClcontaining0.1%sodiumazide. |
StorageandShippingInformation | |
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StorageConditions | Maintainbetween2and8°Cinundilutedaliquotsforupto6months. |
Applications | |
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Application | DetectChondroitinSulfateProteoglycanusingthisAnti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27validatedforuseinFC,IF&IP. |
KeyApplications |
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ApplicationNotes | Immunofluorescencemicroscopyofcellsinculture(Bumoietal.,1984;Schrappeetal.,1992).Also,LeggJetal(2003)Development130:6049-6063{3%PFAfixedfrozensections}. Immunoelectronmicroscopy(Bumoietal.,1984) Immunoprecipitation:1μg/10E6cells(Bumoietal.,1984;Morganetal.,1981) FACSanalysis:1-2μg/10E6cells FunctionalblockofmelanomacellspreADIng(Morganetal.,1981),gliomacellproliferation3andtumorgrowthinnudemice(Morganetal.,1981;Schrappeetal.,1992). Optimalworkingdilutionsmustbedeterminedbyenduser. |
BIOLOGicalInformation | |
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Immunogen | HumanM14melanomacellextractdepletedoffibronectinandboundbylensculinarislectin-Sepharose™(Morganetal.,1981). |
Clone | 9.2.27 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Recognizesmaturechondroitinsulfateproteoglycancoreglycoproteinof250kDaaswellasprecursorpolypeptidesof210,220and240kDa(Bumoietal.,1984).Reactswithhumanmelanoma,gliomaandproliferatingbrainendothelialcells. |
Isotype | IgG2a |
SpeciesReactivity |
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AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Ahumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreadingonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells. |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades. SIZE:2322aminoacids;250497Da SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16. SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity). TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells. PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity). SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains. MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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