Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1596 |
| Description | Anti-SIRT3(CT)Antibody |
| AlternateNames |
|
| BackgroundInformation | SIRT3isamemberoftheclassIsirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.SIRT3islocatedinthemitochondriaandhasbeenimplicatedinregulatingmetabolicprocesses.EndogenousSIRT3isasolubleproteinlocatedinthemitochondrialmatrix.OverexpressionofSirt3inculturedcellsincreasesrespirationanddecreasestheproductionofreactiveoxygenspecies.FastingincreasesSirt3expressioninwhiteandbrownADIposetissue.AlongerformofSIRT3ispresentinthenucleuswhereitexhibitshistonedeacetylaseactivity.SIRT3protectscardiomyocytesfromstressmediatedcelldeathduetodeacetylationofanuclearfactor,Ku-70. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.09%NaN3. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8°Cfromdateofreceipt.Forlongtermstorage,storeat-20ºC.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | Anti-SIRT3(C-terminus)AntibodyisaRabbitPolyclonalAntibodyfordetectionofSIRT3(C-terminus)alsoknownsirtuin3&hasbeenvalidatedinWB,ELISA&IHC. |
| KeyApplications |
|
| ApplicationNotes | ELISA: ThisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforELISA(1:1000). Immunohistochemistry: Thisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforhistochemistryusinghumanhepatocarcinomatissue(1:50–1:100). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | TheimmunogenwasapeptidecorrespondingtheC-terminalregionofhumanSIRT3. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesSIRT3.Endogenouslevelsofthisproteinvaryamongcelllines;theproteinwaseasilydetectedinRAW264.7andC2C12cellsbutonlyweaklydetectedinHeLacells,andnotdetectedinJurkat,HEK293orPC3cells. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse.Nottestedinotherspecies. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twoalternativelysplicedtranscriptvariantsthatencodedifferentproteinshavebeendescribedforthisgene.[providedbyRefSeq]. |
| GeneSymbol |
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| PurificationMethod | Purified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:NAD-dependentdeacetylase.DespitesomeABIlitytodeacetylatehistonesinvitro,itisunlikelyinvivo. CatalyticactivityNAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.Ref.4Ref.5 CofactorBinds1zincionpersubunitBysimilarity. SUBCELLULARLOCATION:Mitochondrionmatrix.Ref.4Ref.5 TISSUESPECIFICITY:Widelyexpressed.Ref.5Ref.1 PTM:Processedbymitochondrialprocessingpeptidase(MPP)togivea28kDaproduct.Suchprocessingisprobablyessentialforitsenzymaticactivity. SEQUENCESIMILARITY:Belongstothesirtuinfamily. Contains1deacetylasesirtuin-typedomain. |
| MolecularWeight | 44kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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