密理博/07-131 |抗Sirt1（Sir2）抗体/07-131/200µ；L
市场价：
¥8420.00
美元价：
5052.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-131 |
| Replaces | 05-707 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-Sirt1(Sir2)Antibody |
| AlternateNames |
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| BackgroundInformation | SirtuinsareafamilyofcloselyrelatedenzymesnamedaftertheyeastgeneSir2(silentmatingtypeinformationregulation2).MembersoftheSirtuinfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Sirtuinshavebeenimplicatedintheregulationofaging,transcription,apoptosisandstressresistance.Sirt1(alsoknownasSirtuin1,Sir2L1,andSir2a),themammalianhomologofyeastSir2,hasbeenshowntodeacetylateandtherebydeactivatethep53proteintoregulatecellularprocesses. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
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| Presentation | PurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%sodiumazideand30%gylcerol |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 1yearat-20°Cfromdateofshipment. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C. Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GST-taggedfusionproteincorrespondingtoaminoacids1-131ofmouseSir2α. |
| Epitope | a.a.1-131 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesSirt1. |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twotranscriptvariantsresultfromalternativesplicingofthisgene. |
| GeneSymbol |
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| PurificationMethod | ImmunoaffinityChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Essentialduringembryogenesisandgametogenesis.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo. CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein. COFACTOR:Binds1zincionpersubunit(Bysimilarity). ENZYMEREGULATION:Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone)(Bysimilarity).Inhibitedbynicotinamide. SUBUNIT:InteractswithMLLT7/FOXO4,HES1,HEY2andPML(Bysimilarity).FoundinacomplexwithPCAFandMYOD1.Interactswithp53/TP53.InteractswithTAF1B. SUBCELLULARLOCATION:Nucleus(Bysimilarity).Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML(Bysimilarity). TISSUESPECIFICITY:Widelyexpressed.Weaklyexpressedinliverandskeletalmuscle. SIMILARITY:Belongstothesirtuinfamily. SIMILARITY:Contains1deacetylasesirtuin-typedomain. |
| MolecularWeight | 110kDa;Uncharacterizedbands70and50observedinsomeLysates. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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