Millipore/05-1243 |抗Sirt1抗体，克隆3H10.2/05-1243/100µ；G
市场价：
¥8420.00
美元价：
5052.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-1243 |
| Replaces | 05-707 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Sirt1Antibody,clone3H10.2 |
| BackgroundInformation | TheSir2proteininyeastisknowntofunctionintranscriptionalsilencingprocessesthroughthedeacetylationofhistonesH3andH4.ThemorerecentlydescribedhumanhomologueofSir2,knownasSIRT1,hasbeenfoundtoassociatewiththetumorsuppressorproteinp53.TherearenowfivedescribedhumanhomologsofyeastSir2,whicharenamedSIRT1-5. SIRT1bindsanddeacetylatesp53withspecificityforitsC-terminalLys382residueinresponsetotheupregulationofpromyelocyticleukemiaprotein(PML)nuclearbodiesoroncogenicRas.Thedeacetylationofp53SIRT1hasbeenshowntonegativelyregulatep53-mediatedtranscription,preventingcellularsenescenceandapoptosisinducedbyDNAdamageandstress.SIRT1isaHDACwhichisimportantinestablishingrepressivechromatinstructuresandplaysaroleinincreasingLifespan. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedinPBSwith0.05%SodiumAzide |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GSTfusionproteincorrespondingtoaminoacids508-616ofhumanSirt1. |
| Clone | 3H10.2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | HumanSirt1.DoesnotcrossreactwithlysatesfrommouseNIH/3T3cellsorratPC12cells. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q96EB6#NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsABIlitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein. COFACTOR:Binds1zincionpersubunit(Bysimilarity). SIZE:747aminoacids;81681Da SUBUNIT:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1(Bysimilarity).InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML. SUBCELLULARLOCATION:Nucleus.Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML.TISSUESPECIFICITY:Widelyexpressed. SIMILARITY:SwissProt:Q96EB6##Belongstothesirtuinfamily.&Contains1deacetylasesirtuin-typedomain. MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedlifespanasithasbeenobservedinyeast. |
| MolecularWeight | 120kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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