Millipore/MAB2013 |抗K-钙粘蛋白抗体，细胞外结构域，克隆2B6/MAB2013/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB2013 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-K-CadherinAntibody,extracellulardomain,clone2B6 |
| AlternateNames |
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| BackgroundInformation | CadherinsconstituteafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcell-cellinteractions.Themembersofthisfamilyaredifferentiallyexpressedinvarioustissues.Theyfunctioninthemaintenanceoftissueintegrityandmorphogenesis.Thecadherinsgenerallycontainfiveextracellularrepeats,atransmembranedomainandacytoplasmictailthatbindstothecateninfamilyofcytoskeletalanchoringproteinswhichalsofunctionassignaltransducers.TheextracellulardomainsareresponsIBLeforthespecificityofhomophilicinteractionsbetweencellsexpressingthesamecadherin.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin,cadherin-1oruvomorulin),neuralcadherin(N-cadherinorcadherin-2),placentalcadherin(P-cadherinorcadherin-3)andretinalcadherin(R-cadherinorcadherin-4).Kidneycadherin(K-cadherinorcadherin-6)andosteoblastcadherin(OB-cadherinorcadherin-11)aretypeIIcadherins.Cadherin-6isexpressedintheproximaltubuleepitheliumofthekidneyfromwhichmostrenalcellcarcinomasarederived. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Purifiedimmuoglobulin.LiquidinPBScontaining0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 1yearat4°Cfromdateofshipment |
| Applications | |
|---|---|
| Application | Anti-K-CadherinAntibody,extracellulardomain,clone2B6detectslevelofK-Cadherin&hasbeenpublished&validatedforuseinWB,IC,IH. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:1:25-1:250 Immunohistochemistry:1:25-1:50;Frozentissuesectionswithavidin-biotinylatedhorserADIshperoxidasecomplex(ABC)asthedetectionmethod. I/ |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | AffinitypurifiedextracellulardomainofhumanK-cadherin |
| Epitope | extracellulardomain |
| Clone | 2B6 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ReactswiththeextracellulardomainofK-cadherin. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesatypeIIclassicalcadherinfromthecadherinsuperfamily.Theencodedmembraneproteinisacalciumdependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Cadherinsmediatecell-cellbindinginahomophilicmanner,contributingtothesortingofheterogeneouscelltypesandthemaintenanceoforderlystructuressuchasepithelium.Strongtranscriptionalexpressionofthisgenehasbeenobservedinhepatocellularandrenalcarcinomacelllines,suggestingapossibleroleinmetastasisandinvasion. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55285#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes. SIZE:790aminoacids;88309Da SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Highlyexpressedinbrain,cerebellum,andkidney.Lung,pancreas,andgastricmucosashowaweakexpression.Alsoexpressedincertainliverandkidneycarcinomas. SIMILARITY:SwissProt:P55285##Contains5cadherindomains. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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