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Millipore/AB1956 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr731]/AB1956/100 µL
![Millipore/AB1956 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr731]/AB1956/100 µL](https://www.ebiomall.cn/images/millipore/201710/Antibody_STD[Antibody_STD-ALL].jpg)
Millipore/AB1956 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr731]/AB1956/100 µL
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1956 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-VE-CadherinAntibody,phospho-specific[Tyr731] |
| AlternateNames |
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| BackgroundInformation | VE-cadherinisanendothelialspecificadhesionmoleculethatisessentialforthemaintenanceofendothelialbarrierfunctionandangiogenesis.ItislinkedtotheactinCytoskeletonthroughanumberofadaptorproteinsincludingalpha,beta,andgammacatenin.CytoskeletaldynamicsandphosphorylationregulateVE-cadherinmediatedcell-celladhesion.Phosphorylationoftyrosine731leadstotheseparationofbeta-cateninfromthecytoplasmictailofVE-cadherin.Thisphosphorylationeventissufficienttomaintaincellsinamesenchymalstateduringthecellinvasionphaseofangiogenesis. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Antibodyiscross-adsorbedtononphospho-peptidecorrespondingtothesiteofphosphorylationthenaffinitypurifiedusingphosphorylatedVE-cadherin(Tyr731)peptide.Antibodyissuppliedin100μLphosphate-bufferedsaline(noCa2+,noMg2+),pH7.3,50%glycerol,1mg/mLBSA,and0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cforuptooneyearfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.Maybestoredforshortperiodsat2-8°C. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidecorrespondingtoaminoacidresiduessurroundingandincludingtyrosine731(phosphorylated)ofhumanVE-Cadherin.Theimmunogensequenceis100%identicalinchimpanzee,mouse,rat,chicken,zebrafish,cow,dogand91%identicalinpigVE-cadherin. |
| Epitope | Tyr731 |
| Host | Rabbit |
| Specificity | Theantibodydetectsa120kDaproteincorrespondingtoVE-cadherin. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains. |
| MolecularWeight | 120kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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