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Millipore/AB1955 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]/AB1955/100 µL
![Millipore/AB1955 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]/AB1955/100 µL](https://www.ebiomall.cn/images/millipore/201710/Antibody_STD[Antibody_STD-ALL].jpg)
Millipore/AB1955 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]/AB1955/100 µL
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1955 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-VE-CadherinAntibody,phospho-specific[Tyr658] |
| BackgroundInformation | VE-cadherinisanendothelialspecificadhesionmoleculethatisessentialforthemaintenanceofendothelialbarrierfunctionandangiogenesis.ItislinkedtotheactinCytoskeletonthroughanumberofadaptorproteinsincludingalpha,beta,andgammacatenin.CytoskeletaldynamicsandphosphorylationregulateVE-cadherinmediatedcellcelladhesion.Theinteractionbetweencytosolicc-terminalSrckinase,SH2domainandphosphorylatedtyrosine658siteofVE-Cadherinregulatesdensitydependentcellproliferation.Phosphorylationoftyrosine658hasbeenshowntoleadtouncouplingofp120-cateninfromthecytoplasmictailofVE-cadherin.Thisphosphorylationeventissufficienttomaintaincellsinamesenchymalstateduringthecellinvasionphaseofangiogenesis. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Antibodyispurifiedfromrabbitserum.Itiscross-adsorbedtononphospho-peptidecorrespondingtothesiteofphosphorylationthenaffinitypurifiedusingphosphorylatedVEcadherin(Tyr658)peptide.Antibodyissuppliedin100µlphosphate-bufferedsaline(noCa2+,noMg2+),pH7.3,50%glycerol,containing1mg/mlBSA,and0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cforuptooneyearor2°-8°Cforshorttermstoragefromdateofreceipt. Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | Anti-VE-CadherinAntibody,phospho-specific[Tyr658]detectslevelofVE-Cadherin&hasbeenpublished&validatedforuseinWB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | PhosphorylatedVE-cadherin(Tyr658)syntheticpeptidecorrespondingtohumanaminoacidresiduesaroundtyrosine658.Thesequenceisconservedinmouse,rat,porcine,bovine,canine,chickenandchimpanzee. |
| Host | Rabbit |
| Specificity | Theantibodydetectsa120kDaproteinofVE-cadherin. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Thissequenceis100%homologousinmouse,rat,chicken,chimpanzee,cow,dogandpigVE-cadherin. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
| GeneSymbol |
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| Modifications |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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