Millipore/CBL263 |抗MUC-1抗体，12肽表位，克隆VU 3C6/CBL263/100µ；G
市场价：
¥4920.00
美元价：
2952.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | CBL263 |
| Replaces | CBL264 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-MUC-1Antibody,12-merepitope,cloneVU3C6 |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Themonoclonalispresentedataconcentrationof100μg/1mlinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Forusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20°C. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | HumanbreastcancercelllineZR-75-1. |
| Epitope | 12-merepitope |
| Clone | VU3C6 |
| Host | Mouse |
| Specificity | Theantibodyreactswiththeextracellular12-merGVTSAPDTRPAPepitopeoftheMUC-1tandemrepeat. |
| Isotype | IgG1 |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisamemberofthemucinfamilyandencodesamembranebound,glycosylatedphosphoprotein.Theproteinisanchoredtotheapicalsurfaceofmanyepitheliabyatransmembranedomain,withthedegreeofglycosylationvaryingwithcelltype.Italsoincludesa20aavariablenumbertandemrepeat(VNTR)domain,withthenumberofrepeatsvaryingfrom20to120indifferentindividuals.Theproteinservesaprotectivefunctionbybindingtopathogensandalsofunctionsinacellsignalingcapacity.Overexpression,aberrantintracellularlocalization,andchangesinglycosylationofthisproteinhavebeenassociatedwithcarcinomas.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentisoformsofthisgenehavebeenreported,butthefull-lengthnatureofonlysomehasbeendetermined. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P15941#Isoform7behavesasareceptorandbindsthesecretedisoform5.Thebindinginducesthephosphorylationoftheisoform7,alterscellularmorphologyandinitiatescellsignaling.CanbindtoGRB2adapterprotein. SIZE:1255aminoacids;122072Da SUBUNIT:Thecleavedform(onlytheisoform1)ofMUC1formsatightheterodimerwiththereleasedC-terminalpeptide(whichisfirstsecretedtobeextracellular). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform5:Secreted.&Isoform9:Secreted. TISSUESPECIFICITY:ExpressedonductalepithelialcellsandonactivatedT-cells.Aberrantlyglycosylatedformsexpressedinhumanepithelialtumors,suchasbreastorovariancancerandalsoinnon-epithelialtumorcells.Isoform7expressedonlyintumoralcells. PTM:Highlyglycosylated(N-andO-linkedcarbohydratesandsialicacid).Inthe20aminoacidtandemrepeatpositions5(Ser),6(Thr),14(Thr),15(Ser)and19(Thr)areO-glycosylated(GalNAc).TheaveragedensityofO-glycosylatedsiteswithinrepeatpeptidesvarieswithcelldifferentiationfromabout50%inlactation-associatedMUC1toover90%inavarietyofbreastcancercells.&Isoform1andisoform7undergoestransphosphorylationonserineandtyrosineresidues. SIMILARITY:SwissProt:P15941##Contains1SEAdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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