Millipore/05-652 |抗MUC1/表皮素抗体，克隆214D4/05-652/200µ；G
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-652 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-MUC1/episialinAntibody,clone214D4 |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| Applications | |
|---|---|
| Application | Anti-MUC1/episialinAntibody,clone214D4detectslevelofMUC1/episialin&hasbeenpublished&validatedforuseinFC,IH. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Fusionprotein,humanb-gal-episialin/MUC1repeatdomain |
| Clone | clone214D4 |
| Host | Mouse |
| Specificity | MUC1/episialin |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisamemberofthemucinfamilyandencodesamembranebound,glycosylatedphosphoprotein.Theproteinisanchoredtotheapicalsurfaceofmanyepitheliabyatransmembranedomain,withthedegreeofglycosylationvaryingwithcelltype.Italsoincludesa20aavariablenumbertandemrepeat(VNTR)domain,withthenumberofrepeatsvaryingfrom20to120indifferentindividuals.Theproteinservesaprotectivefunctionbybindingtopathogensandalsofunctionsinacellsignalingcapacity.Overexpression,aberrantintracellularlocalization,andchangesinglycosylationofthisproteinhavebeenassociatedwithcarcinomas.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentisoformsofthisgenehavebeenreported,butthefull-lengthnatureofonlysomehasbeendetermined. |
| GeneSymbol |
|
| PurificationMethod | ProteinGChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P15941#Isoform7behavesasareceptorandbindsthesecretedisoform5.Thebindinginducesthephosphorylationoftheisoform7,alterscellularmorphologyandinitiatescellsignaling.CanbindtoGRB2adapterprotein. SIZE:1255aminoacids;122072Da SUBUNIT:Thecleavedform(onlytheisoform1)ofMUC1formsatightheterodimerwiththereleasedC-terminalpeptide(whichisfirstsecretedtobeextracellular). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform5:Secreted.&Isoform9:Secreted. TISSUESPECIFICITY:ExpressedonductalepithelialcellsandonactivatedT-cells.Aberrantlyglycosylatedformsexpressedinhumanepithelialtumors,suchasbreastorovariancancerandalsoinnon-epithelialtumorcells.Isoform7expressedonlyintumoralcells. PTM:Highlyglycosylated(N-andO-linkedcarbohydratesandsialicacid).Inthe20aminoacidtandemrepeatpositions5(Ser),6(Thr),14(Thr),15(Ser)and19(Thr)areO-glycosylated(GalNAc).TheaveragedensityofO-glycosylatedsiteswithinrepeatpeptidesvarieswithcelldifferentiationfromabout50%inlactation-associatedMUC1toover90%inavarietyofbreastcancercells.&Isoform1andisoform7undergoestransphosphorylationonserineandtyrosineresidues. SIMILARITY:SwissProt:P15941##Contains1SEAdomain. |
| MolecularWeight | nonegiven |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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