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Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL
Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABS77 |
| Replaces | 04-361 |
| Description | Anti-GSK-3alpha/betaAntibody,clone12B11.1 |
| AlternateNames |
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| BackgroundInformation | Glycogensynthase-3alpha(GSK-3alpha)isaubiquitousconstitutively-activemultifunctionalkinase.GSK-3alphaphosphorylatesserineandthreonineresiduesonitstargetsubstrates,mostofwhichare“primed”orprephosphorylated.ItismostwidelyresearchedforitsinteractionwithglycogensynthasewhichisdeactivatedafterphosphorylationbyGSK-3alpha;thisactivityblocksthesynthesisofglycogenandplaysanimportantroleintheregulationofglycogen.GSK-3alphaisalsoinvolvedintheWnt/β-catenin,Notch,andHedgehogsignalingpathwaysandaffectsawiderangeofcellularprocessesincludingcell-cycleregulation,transcription,andapoptosis.GSK-3alphaalsophosphorylatestauproteinsandmaycontributetothegenerationofAPP-derivedamyloidplaqueswhichareinvolvedinthepathogenesisofAlzheimer’sdisease.GSK-3alphaisalsoinvestigatedforitsroleintype2diabetes,andcancer. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Ovalbumin-conjugatedlinearpeptidecorrespondingtohumanGSK-3alpha/beta. |
| Clone | 12B11.1 |
| Host | Mouse |
| Isotype | IgMκ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesamultifunctionalSer/Thrproteinkinasethatisimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase,andtranscriptionfactors,suchasJUN.ItalsoplaysaroleintheWNTandPI3Ksignalingpathways,aswellasregulatestheproductionofbeta-amyloidpeptidesassociatedwithAlzheimer"sdisease.[providedbyRefSeq,Oct2011]. |
| GeneSymbol |
|
| PurificationMethod | PurifiedbyIon-ExchangeChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Constitutivelyactiveproteinkinasethatactsasanegativeregulatorinthehormonalcontrolofglucosehomeostasis,Wntsignalingandregulationoftransctiptionfactorsandmicrotubules,byphosphorylatingandinactivatingglycogensynthase(GYS1orGYS2),CTNNB1/beta-catenin,APCandAXIN1.Requiresprimedphosphorylationofthemajorityofitssubstrates.ContributestoinsulinregulationofglycogensynthesisbyphosphorylatingandinhibitingGYS1activityandhenceglycogensynthesis.Regulatesglycogenmetabolisminliver,butnotinmuscle.Mayalsomediatethedevelopmentofinsulinresistancebyregulatingactivationoftranscriptionfactors.InWntsignaling,regulatesthelevelandtranscriptionalactivityofnuclearCTNNB1/beta-catenin.Facilitatesamyloidprecursorprotein(APP)processingandthegenerationofAPP-derivedamyloidplaquesfoundinAlzheimerdisease.Maybeinvolvedintheregulationofreplicationinpancreaticbeta-cells.Isnecessaryfortheestablishmentofneuronalpolarityandaxonoutgrowth. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ATP+aprotein=ADP+aphosphoprotein. ENZYMEREGULATION:ActivatedbyphosphorylationatTyr-279.Inresponsetoinsulin,inhibitedbyphosphorylationatSer-21byPKB/AKT1;phosphorylationatthissitecausesaconformationalchange,preventingaccessofsubstratestotheactivesite.Inhibitedbylithium. SUBUNITSTRUCTURE:Monomer.InteractswithARRB2(Bysimilarity).InteractswithAXIN1andCTNNB1/beta-catenin. PTM:PhosphorylatedbyAKT1atSer-21:uponinsulin-mediatedsignaling,theactivatedPKB/AKT1proteinkinasephosphorylatesanddesactivatesGSK3A,resultinginthedephosphorylationandactivationofGYS1.ActivatedbyphosphorylationatTyr-279. MISCELLANEOUS:HigherexpressionandactivityofGSK3Aarefoundintheskeletalmuscle(vastuslateralis)ofpatientswithtype2diabetes(Ref.5).SeveralpotentGSK3(GSK3AandGSK3B)inhibitorshavebeenidentifiedandcharacterizedinpreclinicalmodelsfortreatmentsoftype2diabetes(Ref.17). SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain. |
| MolecularWeight | ~46/51kDaobserved |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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