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当前位置: 首页 > 产品中心 > Functional_antibody > 密理博/FCMAB386F |密理马克™ 抗GSK3-FITC抗体,克隆4G-1E/FCMAB386F/100试验
商品详细密理博/FCMAB386F |密理马克™ 抗GSK3-FITC抗体,克隆4G-1E/FCMAB386F/100试验
密理博/FCMAB386F |密理马克™ 抗GSK3-FITC抗体,克隆4G-1E/FCMAB386F/100试验
密理博/FCMAB386F |密理马克™ 抗GSK3-FITC抗体,克隆4G-1E/FCMAB386F/100试验
商品编号: FCMAB386F
品牌: 密理博
市场价: ¥5340.00
美元价: 3204.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberFCMAB386F
TradeName
  • Milli-Mark
DescriptionMilli-Mark™Anti-GSK3-FITCAntibody,clone4G-1E
AlternateNames
  • GSK-3alpha
  • glycogensynthasekinase3alpha
BackgroundInformationGlycogensynthasekinase-3(GSK-3),amultifunctionalserine/threoninekinase,isakeyregulatorofnumeroussignalingpathways.TwoisoformsofGSK-3arereportedinmammals:a51kDaGSK-3aanda47kDaGSK-3b.Thesetwoisoformsexhibitabout98%homologyintheirkinasedomains,butshareonlyabout36%identityinthelast76C-terminalaminoacidresidues.GSK-3acontainsaglycine-richextensionatitsN-terminus.Aminor(~15%oftotal)splicevariantofGSK-3b,GSK-3b2,hasalsobeenidentified,whichcontainsa13-residueinsertwithinthekinasedomain.Itexhibitsreducedkinaseactivitytowardstauproteincomparedwith‘unspliced’GSK-3b.GSK-3b2islocalizedprimarilytoneuronalcellbodies,unlikeunsplicedGSK-3bthatisalsofoundinneuronalprocesses.GSK-3bplaysakeyinhibitoryroleintheWntsignalingpathway.Wntgenesencodealargefamilyofsecreted,cysteine-richproteinsthatareimportantindevelopmentandinmaintenanceofadulttissues.AbnormalitiesinWntsignalingarereportedtopromotebothhumandegenerativediseasesandcancer.
ProductInformation
FormatFITC
Control
  • Jurkatcells
PresentationPurifiedmousemonoclonalIgG1conjugatedtoFITCinPBSwith0.1%sodiumazideand15mg/mLBSA.
StorageandShippingInformation
StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
Applications
ApplicationMilli-MarkAnti-GSK3-FITCAntibody,clone4G-1EdetectslevelofGSK3&hasbeenpublished&validatedforuseinFC.
KeyApplications
  • FlowCytometry
BIOLOGicalInformation
ImmunogenSyntheticpeptidederivedfromaregionofthecatalyticdomain(betweensuBDomainVIIandVIII)oftheDrosophilaGSK3/shaggyenzyme,coupledtoovalbumin.
Clone4G-1E
HostMouse
SpecificityAntibodyrecognizesGSK3.
IsotypeIgG1
SpeciesReactivity
  • Human
SpeciesReactivityNoteTestedandpassedonHuman.UnconjugatedantibodyCat.No.05-412isknowntoreactwithMouse,Rat,Dictyostelium,andVertebrates.
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • GSK3A
  • DKFZp686D0638
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity).

SIZE:483aminoacids;50981Da

SUBUNIT:Monomer(Bysimilarity).

SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1protein
MolecularWeight51kDaCalculated
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。