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Millipore/07-1413 | Anti-GSK-3b Antibody, a.a. 335-349/07-1413/50 µg
Millipore/07-1413 | Anti-GSK-3b Antibody, a.a. 335-349/07-1413/50 µg
市场价:
¥6160.00
美元价:
3696.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 07-1413 |
Replaces | AB8687 |
Description | Anti-GSK-3bAntibody,a.a.335-349 |
BackgroundInformation | GSK3(GlycogenSynthaseKinase3)differsfrommostserine/threoninekinasesinthatitisactiveintheabsenceoftheactionofsignalingpathways.Twoisoformsexist,GSK3αandGSK3β.ThefunctionofGSK3istophosphorylateGlycogenSynthaseandtherebyinactivateit.InsulinactionstimulatesthePI3Kinasepathway,resultinginAktactivation,whichphosphorylatesandinactivatesGSK3.GlycogenSynthaseisthenrapidlydephosphorylatedandactivated.OtherGSK3substratesincludeJun(oninhibitorysites),andeIF2B.PhosphorylationofTaubyGSK3mayrelatetodevelopmentofAlzheimer"sdisease.Phosphorylationstate-specificantibodiesdirectedagainsttheAktsite(Ser21)onGSK3aresuitableforsurrogateassaysoftheactivationstateofthepathway. |
ProductInformation | |
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Format | AffinityPurified |
Control |
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Presentation | PurifiedpolyclonalIgGantibodyissuppliedinPBS,pH7.2,50%glyceroland0.09%sodiumazide. |
StorageandShippingInformation | |
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StorageConditions | Stableat–20ºCforuptooneyearfromdateofreceipt.Productmaybestoredatfor2-4weeksat2º-8ºC. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
BIOLOGicalInformation | |
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Immunogen | RatGSK3betasyntheticpeptide(aa.335-349),conjugatedtoKLH.Thissequenceis100%identicaltohumanGSK3beta. |
Epitope | a.a.335-349 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Thisantibodydetectsastrong47kDaprotein,correspondingtotheexpectedmolecularmassofGSK3beta. |
Isotype | IgG |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandnactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM]. |
GeneSymbol |
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PurificationMethod | ProteinAaffinitypurified |
UniProtNumber | |
UniProtSummary | FUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1. SUBUNIT:Monomer(Bysimilarity).InteractswithCABYR,MUC1,NINandPRUNE. ALTERNATIVEPRODUCTS:2namedisoforms[FASTA]producedbyalternativesplicing. |
MolecularWeight | Thisantibodydetectsastrong47kDaprotein. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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