密理博/05-413 |抗磷酸-GSK3（Tyr279/Tyr216）抗体，克隆5G-2F/05-413/200µ；G
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-413 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-phospho-GSK3(Tyr279/Tyr216)Antibody,clone5G-2F |
| AlternateNames |
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| BackgroundInformation | Glycogensynthasekinase3(GSK3)isaprolinedirectedserinethreoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase,akeyenzymeinglycogenmetabolism.Sincethen,ithasbeenshowntobeinvolvedintheregulationofadiversearrayofcellularfunctions,includingproteinsynthesis,cellproliferation,celldifferentiation,microtubuleassembly/disassembly,andapoptosis. ThereexiststwoisoformsofGSK3,alphaandbeta,andtheyshowahighdegreeofaminoacidhomology.ThetwoisoformsofGSK3arestrictlyregulatedviaphosphorylation.ActivationofGSK3betaisdependentuponthephosphorylationofTyr216(Tyr279inGSK3alpha).Uponactivation,ithasbeenshowntophosphorylateanumberofdifferentcellularproteins,includingp53,c-Myc,c-Jun,heatshockfactor1(HSF1),andcyclinD1 |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | PurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide.Frozenat-20ºC. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations: Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20ºC.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptide(C-KQLLHGEPNVS[pY]ICSRY)correspondingtoaminoacids203-219derivedfromaregionofthecatalyticdomain(betweensuBDomainVIIandVIII)oftheDrosophilaGSK3/shaggyenzymecoupledtoovalbumin. |
| Epitope | SurroundingpTyr214(DrosophilaGSK-3),pTyr279(humanGSK3α),pTyr216(humanGSK3β) |
| Clone | 5G-2F |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesGSK-3phosphorylatedatthetargettyrosineresidue(humanGSK-3αpY279andGSK-3βpY216).The17-aminoacidimmunogenpeptidesequencediffersfromthecorrespondinghuman,mouse,andratsequencebyonlytwoaminoacidresidues. |
| Isotype | IgG1κ |
| SpeciesReactivity |
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| SpeciesReactivityNote | Human,mouse,andrat.PredictedtoreactwithGSK-3orthologsfromdrosophilamelanogasterandmanyotherspeciesbasedonsequencehomologysurroundingthetargetphosphotyrosineresidue. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscriptionfactors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001)}).[suppliedbyOMIM] |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | ProteinGChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity). SIZE:483aminoacids;50981Da SUBUNIT:Monomer(Bysimilarity). SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1proteinkinasedomain. |
| MolecularWeight | 51kDa(alpha)and46kDa(beta) |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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