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Millipore/04-903 | Anti-GSK3α/β Antibody, rabbit monoclonal/04-903/100 µl
Millipore/04-903 | Anti-GSK3α/β Antibody, rabbit monoclonal/04-903/100 µl
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-903 |
| Replaces | 05-903 |
| Description | Anti-GSK3α/βAntibody,rabbitmonoclonal |
| AlternateNames |
|
| BackgroundInformation | GlycogenSynthaseKinase3differsfrommostserine/threoninekinasesinthatitisactiveintheabsenceoftheactionofsignalingpathways.Twoisoformsexist,GSK3αandGSK3β.ThefunctionofGSK3istophosphorylateGlycogenSynthaseandtherebyinactivateit.InsulinactionstimulatesthePI3Kinasepathway,resultinginAktactivation,whichphosphorylatesandinactivatesGSK3.GlycogenSynthaseisthenrapidlydephosphorylatedandactivated.OtherGSK3substratesincludeJun(oninhibitorysites),andeIF2B.PhosphorylationofTaubyGSK3mayrelatetodevelopmentofAlzheimer"sdisease.Phosphorylationstate-specificantibodiesdirectedagainsttheAktsite(Ser21)onGSK3aresuitableforsurrogateassaysoftheactivationstateofthepathway. |
| ProductInformation | |
|---|---|
| Format | CultureSupernatant |
| Control |
|
| Presentation | Culturedsupernantantcontaining0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | ThisAnti-GSK3α/βAntibodyisvalidatedforuseinWB,IPforthedetectionofGSK3α/β. |
| KeyApplications |
|
| ApplicationNotes | Immunoprecipitation:2-8μLofapreviouslotofantibodyimmunoprecipitatedGSK3alphaandbetafrom100μgofHEK293RIPAlysate. NOTE:ThisantibodyalsosuccessfullyimmunoprecipitatedGSK3alphaandbetausingtheCatchandRelease®v2.0ReversIBLeImmunoprecipitationSystem(Catalog#17-500). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | N-terminal6His-taggedrecombinantfulllengthhumanGSK3β. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | GSK3alphaandbeta. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Humanandmouse. Predictedtocross-reactwithratbasedonsequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase, homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolof severalregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscription factors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001) |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUNBysimilarity. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. SUBUNITSTRUCTURE:MonomerBysimilarity. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain. |
| MolecularWeight | ~46kDa(beta)and51kDa(alpha) |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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