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Millipore/MAB1628 | Anti-Myosin Antibody, slow muscle, clone NOQ7.5.4D/MAB1628/100 µg
Millipore/MAB1628 | Anti-Myosin Antibody, slow muscle, clone NOQ7.5.4D/MAB1628/100 µg
市场价：
¥4920.00
美元价：
2952.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1628 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-MyosinAntibody,slowmuscle,cloneNOQ7.5.4D |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Liquid. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°C. |
| Applications | |
|---|---|
| Application | Anti-MyosinAntibody,slowmuscle,cloneNOQ7.5.4DisanantibodyagainstMyosinforuseinRIA,WB,IH. |
| KeyApplications |
|
| ApplicationNotes | Immunohistochemistry:frozenandformalinfixedsections. Immunoblotting RIA Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Myosinpurifiedfrommyofibrilsisolatedfromhistochemicallymixedhumanskeletalmuscle. |
| Epitope | slowmuscle |
| Clone | NOQ7.5.4D |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Slowmyosinheavychain.ClearlyidentifiesType1fibers.WithinskeletalmuscleMAB1628isspecificforslowmyosinheavychaininawidevarietyofspecies.Itreactsstronglywithratandfelineslowmyosinheavychain.MAB1628alsoidentifiesbeta(slow)myosinheavychaininheartventricles. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | MYH7encodesthecardiacmusclebeta(orslow)isoformofmyosin.ChangesintherelativeabundanceofMYH7andMYH6(thealpha,orfast,isoformofcardiacmyosinheavychain)correlatewiththecontractilevelocityofcardiacmuscle.MutationsinMYH7areassociatedwithfamilialhypertrophiccardiomyopathy. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P12883#Musclecontraction. SIZE:1935aminoacids;223097Da SUBUNIT:Musclemyosinisahexamericproteinthatconsistsof2heavychainsubunits(MHC),2alkalilightchainsubunits(MLC)and2regulatorylightchainsubunits(MLC-2). SUBCELLULARLOCATION:Cytoplasm,myofibril.Note=Thickfilamentsofthemyofibrils. DOMAIN:SwissProt:P12883Therodliketailsequenceishighlyrepetitive,showingcyclesofa28-residuerepeatpatterncomposedof4heptapeptides,characteristicforalpha-helicalcoiledcoils. DISEASE:SwissProt:P12883#DefectsinMYH7arethecauseoffamilialhypertrophiccardiomyopathytype1(CMH1)[MIM:192600];alsodesignatedFHCorHCM.Hypertrophiccardiomyopathyisaheartdisordercharacterizedbyventricularhypertrophy,whichisusuallyasymmetricandofteninvolvestheinterventricularseptum.Theprevalenceofthediseaseinthegeneralpopulationis0.2%.FHCisclinicallyheterogeneous,withinter-andintrafamilialvariationsrangingfrombenigntomalignantformswithhighriskofcardiacfailureandsuddencardiacdeath.&DefectsinMYH7arethecauseofmyosinstoragemyopathy[MIM:608358].Inthisdisorder,musclebiopsyshowstype1fiberpredominanceandincreasedinterstitialfatandconnectivetissue.Inclusionbodiesconsistingofthebetacardiacmyosinheavychainarepresentinthemajorityoftype1fibers,butnotintype2fibers.&DefectsinMYH7areacauseofdilatedcardiomyopathy(CMD)[MIM:115200].CMDisadisordercharacterizedbycardiacdilationandreducedsystolicfunction.&DefectsinMYH7arethecauseofLaingearly-onsetdistalmyopathy(MPD1)[MIM:160500].MPD1isanautosomaldominantdisorderwhichdiffersfromotherdistalmyopathiesinthatonsetisasearlyas4yearsofage.SelectiveweaknessoftheanteriortibialmusclesisfollowedbyweaknessofthefingerextensorsandselectedproximalmusclegroupssuchasthehipaBDuctorsandrotators,theshoulderabductorsandthesternocleidomastoids. SIMILARITY:Contains1IQdomain.&Contains1myosinhead-likedomain. MISCELLANEOUS:Eachmyosinheavychaincanbesplitinto1lightmeromyosin(LMM)and1heavymeromyosin(HMM).Itcanlaterbesplitfurtherinto2globularsubfragments(S1)and1rod-shapedsubfragment(S2).&Thecardiacalphaisoformisa"fast"ATPasemyosin,whilethebetaisoformisa"slow"ATPase. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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