Millipore/05-716 |抗肌球蛋白重链抗体，克隆A4.1025/05-716/200µ；L
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-716 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-MyosinHeavyChainAntibody,cloneA4.1025 |
| AlternateNames |
|
| BackgroundInformation | MyosinisoneofthetwomajorcomponentsofmuscletissueresponsIBLeforcontraction.Inmusclecellsmyosinisarrangedasthickfilamentousstructuresthatarearrangedinparalleltothinfilamentousstructurescomposedofactin.MusclecontractionisactuatedbythecouplinganduncouplingofthinandthickfilamentsthroughachemicallinkagemediatedbyATP.Thecouplinganduncouplingisarrangedsuchthatthefilamentsslideinonedirectionwhencoupledandinreversedirectionwhenuncoupledorreleased.Myosinandactinalsoservetofacilitatemotilityinnon-musclecellssuchasinslimemoldswhereshorteryetsimilarfilamentousstructuresworktogether.Anincreasingnumberofdifferentmyosinsarebeingdescribed.MyosinIisalowmolecularweightmyosinfoundinprotozoaanddoesnotself-assemble.MyosinIIistheclassicformfoundinmusclecellsthatselfassembleintothickbundles.MyosinIIisamultimericproteinthatiscomposedoftwoheavychainsandtwolightchains. |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | UnpurifiedmouseascitesmonoclonalIgGinbuffercontaining0.07MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideand30%glycerol.Liquidat-20°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap. HandlingRecommendations: Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerol-containingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Partiallypurifiedproteinfromadulthumanskeletalmusclemyosin.CloneA4.1025. |
| Clone | A4.1025 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Thisantibodyrecognizesmyosinheavychain,Mr~220kDa.Immunoblottingwithmusclecelllysateswilloftenshowseveralclosebandsfromdifferentmyosinheavychaingenes,aswellasdegradationproducts. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | MyosinisamajorcontractileproteinwhichconvertschemicalenergyintomechanicalenergythroughthehydrolysisofATP.Myosinisahexamericproteincomposedofapairofmyosinheavychains(MYH)andtwopairsofnonidenticallightchains.Myosinheavychainsareencodedbyamultigenefamily.Inmammalsatleast10differentmyosinheavychain(MYH)isoformshavebeendescribedfromstriated,smooth,andnonmusclecells.Theseisoformsshowexpressionthatisspatiallyandtemporallyregulatedduringdevelopment. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P12882#Musclecontraction. SIZE:1939aminoacids;223115Da SUBUNIT:Musclemyosinisahexamericproteinthatconsistsof2heavychainsubunits(MHC),2alkalilightchainsubunits(MLC)and2regulatorylightchainsubunits(MLC-2). SUBCELLULARLOCATION:Cytoplasm,myofibril.Note=Thickfilamentsofthemyofibrils. DOMAIN:SwissProt:P12882Therodliketailsequenceishighlyrepetitive,showingcyclesofa28-residuerepeatpatterncomposedof4heptapeptides,characteristicforalpha-helicalcoiledcoils. SIMILARITY:Contains1IQdomain.&Contains1myosinhead-likedomain. MISCELLANEOUS:Eachmyosinheavychaincanbesplitinto1lightmeromyosin(LMM)and1heavymeromyosin(HMM).Itcanlaterbesplitfurtherinto2globularsubfragments(S1)and1rod-shapedsubfragment(S2). |
| MolecularWeight | ~220kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
