4000-520-616
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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/07-1651 | Anti-phospho-β Catenin (Ser37) Antibody/07-1651/100 µL
商品详细Millipore/07-1651 | Anti-phospho-β Catenin (Ser37) Antibody/07-1651/100 µL
Millipore/07-1651 | Anti-phospho-β Catenin (Ser37) Antibody/07-1651/100 µL
Millipore/07-1651 | Anti-phospho-β Catenin (Ser37) Antibody/07-1651/100 µL
商品编号: 07-1651
品牌: 密理博
市场价: ¥5960.00
美元价: 3576.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber07-1651
Replaces04-1070
DescriptionAnti-phospho-βCatenin(Ser37)Antibody
AlternateNames
  • BCatenin(pSer37)
  • Beta-catenin
  • catenin(cadherin-associatedprotein),beta1(88kD)
  • catenin(cadherin-associatedprotein),beta1,88kDa
  • cateninbeta-1
BackgroundInformationCateninsareproteinsfoundincomplexeswithcadherincelladhesionmoleculesofanimalcells.Thefirsttwocateninsthatwereidentifiedbecameknownasα-cateninandβ-catenin.α-catenincanbindtoβ-cateninandcanalsobindactin.β-cateninbindsthecytoplasmicdomainofsomecadherins.Whenβ-cateninwassequenceditwasfoundtobeamemberofthearmADIllofamilyofproteins.Theseproteinshavemultiplecopiesoftheso-calledarmadillorepeatdomainwhichisspecializedforprotein-proteinbinding.Anincreaseinβ-cateninproductionhasbeennotedinthosepeoplewhohaveBasalCellCarcinomaandleadstotheincreaseinproliferationofrelatedtumors.Whenβ-cateninisnotassociatedwithcadherinsandα-catenin,itcaninteractwithotherproteinssuchasCateninBetaInteractingProtein1(ICAT)andadenomatosispolyposiscoli(APC).Recentevidencesuggeststhatβ-cateninplaysanimportantroleinvariousaspectsofliverBIOLOGyincludingliverdevelopment(bothembryonicandpostnatal),liverregenerationfollowingpartialhepatectomy,HGF-inducedhepatpomegaly,liverzonation,andpathogenesisoflivercancer.Afterphosphorylation,betacateninisrapidlydegradedintovariousfragmentsovertime(TescoG.,etal.1998.J.Biol.Chem.273(51):33909-33914).
ProductInformation
FormatAffinityPurified
Control
  • Calycullin/OkadoicacidtreatedanduntreatedHEK293celllysate.
PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8ºCfromdateofreceipt.
Applications
ApplicationThisAnti-phospho-βCatenin(Ser37)AntibodyisvalidatedforuseinWBforthedetectionofphospho-βCatenin(Ser37).
KeyApplications
  • WesternBlotting
ApplicationNotesWesternBlotAnalysis:1:500-1:1000dilutionfromarepresentativelotdetectedSer37phosphorylatedbetachaininCalyculinA/OkadoicacidtreatedHEK293celllysate.
BiologicalInformation
ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanPhospho-BCatenin(Ser37)neartheN-terminus.
ConcentrationPleaserefertolotspecificdatasheet.
HostRabbit
SpeciesReactivity
  • Rat
SpeciesReactivityNoteRatandHuman.PredictedtoreactwithMouse,Zebrafish,Xenopus,Chickenbasedon100%sequencehomology.
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
GeneSymbol
  • CTNNB1
  • CTNNB
Modifications
  • Phosphorylation
PurificationMethodAffinityPurfied
UniProtNumber
MolecularWeight~85-90kDaobserved
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。