微孔/AB9598 |抗胶质纤维酸性蛋白δ抗体/AB9598/100µ；L
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB9598 |
| Replaces | 04-1031;04-1062 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-GlialfibrillaryacidicproteinδAntibody |
| AlternateNames |
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| BackgroundInformation | HumanGlialFibrillaryAcidicProteindelta(GFAP-delta)isaGFAPproteinisoformthatisencodedbyanalternativesplicevariantoftheGFAP-gene.Asaresult,GFAP-deltaproteindiffersfromthepredominantspliceform,GFAP-alpha,byitsC-terminalproteinsequence.GFAP-deltaproteinisnotexpressedbyallGFAPexpressingastrocytesbutspecificallybyasubpopulationlocatedinthesubpialzoneofthecerebralcortex,thesubgranularzoneofthehippocampusand,mostintensely,byaribbonofastrocytesfollowingtheependymallayerofthecerebralventricles.Therefore,atleastinthesubventricularzone(SVZ),GFAP-deltaspecificallymarksthepopulationofastrocytesthatcontaintheneuralstemcellsintheadulthumanbrain.Interestingly,theSVZastrocytesactivelyspliceGFAP-deltatranscripts,incontrasttoastrocytesadjacenttothislayer.DatashowsthatGFAP-deltaprotein,unlikeGFAP-alpha,isnotupregulatedinastrogliosis.DataindicatesadifferentfunctionalroleforGFAP-deltainastrocytephysiology.TransfectionstudiesshowedthatGFAP-deltaproteinexpressionhasanegativeeffectonGFAPfilamentformation,andthereforecouldbeimportantformodulatingintermediatefilamentcytoskeletalproperties,possIBLyfacilitatingastrocytemotility.FurtherstudiesonGFAP-deltaandthecellsthatexpressitareimportantforgaininginsightsintoitsfunctionduringdifferentiation,migrationandduringhealthanddisease(Roelofs,RF,etal.,Glia(2005)52:289-300.). |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Rabbitserum.Liquid. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefromhumanGFAP-delta. |
| Host | Rabbit |
| Specificity | GlialFibrillaryAcidicProtein-delta(GFAP-delta).TheantibodydoesnotrecognizeGFAP-alphaprotein. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | DoesNOTreactwithmouseorratGFAP-delta. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.ItisusedasaMarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Anadditionaltranscriptvarianthasbeendescribed,butitsfulllengthsequencehasnotbeendetermined. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P14136#GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells. SIZE:432aminoacids;49880Da SUBUNIT:Isoform3interactswithN-terminusofPSEN1. SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments. DISEASE:SwissProt:P14136#DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse. SIMILARITY:SwissProt:P14136##Belongstotheintermediatefilamentfamily. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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