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Millipore/AB5541 | Anti-Glial Fibrillary Acidic Protein Antibody/AB5541/50 µL
Millipore/AB5541 | Anti-Glial Fibrillary Acidic Protein Antibody/AB5541/50 µL
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5541 |
| Replaces | 04-1031;04-1062 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GlialFibrillaryAcidicProteinAntibody |
| AlternateNames |
|
| BackgroundInformation | Glialfibrillaryacidicprotein(GFAP)isaclass-IIIintermediatefilament.TypeIIIintermediatefilamentscontainthreedomains,themostconservedofwhichistheroddomain.ThespecificsequenceforthisregionoftheproteinmaydifferbetweenthedifferentintermediatefilamentgenesfortypeIIIproteins,butthestructureoftheproteinishighlyconserved.GFAPisthemainconstituentofintermediatefilamentsinastrocytesandservesasacellspecificMarkerthatdistinguishesdifferentiatedastrocytesfromotherglialcellsduringthedevelopmentofthecentralnervoussystem.GFAPisalsofoundinthelensepithelium,Kupffercellsoftheliver,insomecellsinsalivarytumorsandhasbeenreportedinerythrocytes. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | PurifiedchickenpolyclonalinbuffercontainingPBScontaining5mMsodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cinundilutedaliquotsfromdateofreceipt.Donotstoreinaself-defrostingfreezer. HandlingRecommendations: Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedbovineGFAP. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Chicken |
| Specificity | Glialfibrillaryacidicprotein(GFAP).Reactswithbothnativeandrecombinantprotein. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,rat,andmouse.Expectedtocross-reactwithbovineandporcine.Otherspecieshavenotyetbeentested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.Itisusedasamarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Anadditionaltranscriptvarianthasbeendescribed,butitsfulllengthsequencehasnotbeendetermined. |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P14136#GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells. SIZE:432aminoacids;49880Da SUBUNIT:Isoform3interactswithN-terminusofPSEN1. SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments. DISEASE:SwissProt:P14136#DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse. SIMILARITY:SwissProt:P14136##Belongstotheintermediatefilamentfamily.... |
| MolecularWeight | 55kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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