Millipore/09-100 | Anti-RBL2 Antibody/09-100/100 µg
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 09-100 |
| Description | Anti-RBL2Antibody |
| AlternateNames |
|
| BackgroundInformation | RBL2,retinoblastoma-likeprotein2alsoreferredtoasapocketprotein,belongstotheRBfamilyoftumorsuppressors,asdoesanotherpocketproteinp107.Thesepocketproteinsareinvolvedincellproliferation,differentiation,andtransformation.Theyalsoshareasignificantamountofsequencehomology.RBL2isanimportantregulatorofentryincelldivisionandmayactasatranscriptionrepressorbyrecruitingchromatin-modifyingenzymestopromoters. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| Applications | |
|---|---|
| Application | UseAnti-RBL2Antibody(RabbitPolyclonalAntibody)validatedinWBtodetectRBL2alsoknownas130kDaretinoblastoma-associatedprotein. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearproteincorrespondingtohumanRBL2atandaroundtheC-terminus. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesRBL2atandaroundtheC-terminus. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Proventoreactwithhuman.Predictedtoreactwithrat,horse,chimpanzee,ape,anddogbasedonsequencehomology.Mouse(95%). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Keyregulatorofentryintocelldivision.Directlyinvolvedinheterochromatinformationbymaintainingoverallchromatinstructureand,inparticular,thatofconstitutiveheterochromatinbystABIlizinghistonemethylation.RecruitsandtargetshistonemethyltransferasesSUV420H1andSUV420H2,leADIngtoepigenetictranscriptionalrepression.ControlshistoneH4"Lys-20"trimethylation.Probablyactsasatranscriptionrepressorbyrecruitingchromatin-modifyingenzymestopromoters.PotentinhibitorofE2F-mediatedtrans-activation,associatespreferentiallywithE2F5.BindstocyclinsAandE.BindstoandmaybeinvolvedinthetransformingcapacityoftheadenovirusE1Aprotein.Mayactasatumorsuppressor. SIZE:1139aminoacids;128367Da SUBUNIT:InteractswithAATF.InteractswithSUV420H1andSUV420H2(Bysimilarity).InteractswithRINT1. SUBCELLULARLOCATION:Nucleus. PTM:DuringG0andearlyG1phaseofthecellcycle,phosphorylatedonSer-639andon5siteswithinthedomainB.PhosphorylationonSer-672inG1leadstoitsubiquitin-dependentproteolysis. SIMILARITY:Belongstotheretinoblastomaprotein(RB)family. MISCELLANEOUS:G0-restrictedexpression. |
| MolecularWeight | 130kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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