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Millipore/CBL47 | Anti-Transferrin Receptor Antibody/CBL47/100 µg
Millipore/CBL47 | Anti-Transferrin Receptor Antibody/CBL47/100 µg
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | CBL47 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-TransferrinReceptorAntibody |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Thepolyclonalispresentedat100μginphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Forusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20°C. |
| Applications | |
|---|---|
| Application | DetectTransferrinReceptorusingthisAnti-TransferrinReceptorAntibodyvalidatedforuseinELISA. |
| KeyApplications |
|
| ApplicationNotes | Studyofcellularproliferationandlymphocyteactivation. Cellsurfaceexpressionoftransferrinreceptorsiscorrelatedwithrelativecellgrowthrateofmalignantandnon-malignantcells. TransferrinreceptorsarevirtuallyabsentfromrestingPBLs. Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Purifiedhumanplacentaltransferringreceptor |
| Host | Rabbit |
| Specificity | HumanTransferrinReceptorwhichisexpressedonproliferatinglymphoblasts,majorityhumantumourcelllines,normalperipheralbloodmonocytes. AntigenDistribution: ConAactivatedlymphocytes__________67+27% PHAactivatedlymphocytes___________67+27% Monocytes________________________40+20% Thymocytes_______________________22+7% Peripheralbloodlymphocytes_________<3%=""> Bcells(E-)________________________<1%=""> Tcells(E+)________________________<1%=""> NKcells(CD16+)___________________<1%=""> Granulocytes_______________________<> |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P02786#Cellularuptakeofironoccursviareceptor-mediatedendocytosisofligand-occupiedtransferrinreceptorintospecializedendosomes.Endosomalacidificationleadstoironrelease.Theapotransferrin-receptorcomplexisthenrecycledtothecellsurfacewithareturntoneutralpHandtheconcomitantlossofaffinityofapotransferrinforitsreceptor.Transferrinreceptorisnecessaryfordevelopmentoferythrocytesandthenervoussystem(Bysimilarity).Asecondligand,theheditaryhemochromatosisproteinHFE,competesforbindingwithtransferrinforanoverlappingC-terminalbindingsite. SIZE:760aminoacids;84871Da SUBUNIT:Homodimer;disulfide-linked.BindsonetransferrinorHFEmoleculepersubunit.BindstheHLAclassIIhistocompatibilityantigen,DR1.InteractswithSH3BP3. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeIImembraneprotein.Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.&Transferrinreceptorprotein1,serumform:Secreted. PTM:N-andO-glycosylated,phosphorylatedandpalmitoylated.Theserumformisonlyglycosylated.&ProteolyticallycleavedonArg-100toproducethesolubleserumform(sTfR).&PalmitoylatedonbothCys-62andCys-67.Cys-62seemstobethemajorsiteofpalmitoylation. SIMILARITY:SwissProt:P02786##BelongstothepeptidaseM28family.M28Bsubfamily.&Contains1PA(proteaseassociated)domain. MISCELLANEOUS:Serumtransferrinreceptor(sTfR)isusedasameansofdetectingerythropoietin(EPO)misusebyathletesandasadiagnostictestforanemiaresultingfromanumberofconditionsincludingrheumatoidarthritis,pregnancy,irritablebowelsyndromeandinHIVpatients.&Canineandfelineparvovirusesbindhumanandfelinetransferrinreceptorsandusethesereceptorstoenterandinfectcells. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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