Millipore/FCMAB148F |抗Ras-FITC抗体，克隆RAS10/FCMAB148F/100试验
市场价：
¥5340.00
美元价：
3204.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | FCMAB148F |
| Description | Anti-Ras-FITCAntibody,cloneRAS10 |
| AlternateNames |
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| BackgroundInformation | ThetumoroncoproteinsHRas,KRas,andNRasareratedasRasprotoncogenes.PointmutationswithinRasgenesarefrequentlydetectedinhumanmalignanciesandinexperimentallyinducedtumorsinanimals. |
| ProductInformation | |
|---|---|
| Format | FITC |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2aκconjugatedtoFITCinPBSwith0.1%sodiumazideand15mg/mLBSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-Ras-FITCAntibody,cloneRAS10isanantibodyagainstRasforuseinFC. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedrecombinantRas. |
| Clone | RAS10 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Thisantibodyrecognizesp21H-,K-andN-Ras. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| SpeciesReactivityNote | TestedandpassedonHuman.Unconjugatedantibody(05-519)isknowntoreacttoRatandMouse. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | MembersoftheRASsuperfamilyofGTP-bindingproteins,whichincludesMRAS,aremembrane-anchored,intracellularsignaltransducersresponsIBLeforavarietyofnormalcellularfunctions.Theyareoncogenicallyactivatedinasignificantfractionoftumors.[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity. Enzymeregulation:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP). SIZE:189aminoacids;21,656Da SUBUNIT:InteractswithPHLPP(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside. Involvementindisease: DefectsinKRASareacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment. DefectsinKRASareacauseofjuvenilemyelomonocyticleukemia(JMML)[MIM:607785].JMMLisapediatricmyelodysplasticsyndromethatconstitutesapproximately30%ofchildhoodcasesofmyelodysplasticsyndrome(MDS)and2%ofleukemia.ItischaracterizedbyleukocytosiswithtissueinfiltrationandinvitrohypersensitivityofmyeloidProgenitorstogranulocyte-macrophagecolonystimulatingfactor. DefectsinKRASarethecauseofNoonansyndrome3(NS3)[MIM:609942].Noonansyndrome(NS)[MIM:163950]isadisordercharacterizedbydysmorphicfacialfeatures,shortstature,hypertelorism,cardiacanomalies,deafness,motordelay,andableedingdiathesis.Itisageneticallyheterogeneousandrelativelycommonsyndrome,withanestimatedincidenceof1in1000-2500livebirths.Rarely,NSisassociatedwithjuvenilemyelomonocyticleukemia(JMML).NS3inheritanceisautosomaldominant. DefectsinKRASareacauseofcardiofaciocutaneoussyndrome(CFCsyndrome)[MIM:115150];alsoknownascardio-facio-cutaneoussyndrome.CFCsyndromeischaracterizedbyadistinctivefacialappearance,heartdefectsandmentalretardation.Heartdefectsincludepulmonicstenosis,atrialseptaldefectsandhypertrophiccardiomyopathy.Someaffectedindividualspresentwithectodermalabnormalitiessuchassparse,friablehair,hyperkeratoticskinlesionsandageneralizedichthyosis-likecondition.TypicalfacialfeaturesaresimilartoNoonansyndrome.Theyincludehighforeheadwithbitemporalconstriction,hypoplasticsupraorbitalridges,downslantingpalpebralfissures,adepressednasalbridge,andposteriorlyangulatedearswithprominenthelices.TheinheritanceofCFCsyndromeisautosomaldominant. KRASmutationsareinvolvedincancerdevelopment |
| MolecularWeight | ~21kDaCalculated |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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