当前位置：
首页
>
产品中心 >
Functional_antibody >
Millipore/05-516 | Anti-Ras Antibody, clone RAS10/05-516/100 µg
Millipore/05-516 | Anti-Ras Antibody, clone RAS10/05-516/100 µg
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-516 |
| Replaces | CBL751 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-RasAntibody,cloneRAS10 |
| AlternateNames |
|
| BackgroundInformation | ThetumoroncoproteinsHRas,KRas,andNRasareratedasRasprotoncogenes.PointmutationswithinRasgenesarefrequentlydetectedinhumanmalignanciesandinexperimentallyinducedtumorsinanimals. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2akinbuffercontainingPBS,pH7.4,with0.05%sodiumazideand30%glycerol.Liquidat-20°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| Applications | |
|---|---|
| Application | DetectRasusingthisAnti-RasAntibody,cloneRAS10validatedforuseinELISA,FC,IC,IH,IP&WB. |
| KeyApplications |
|
| ApplicationNotes | Immunoprecipitation: 1-4μgofthisantibodyhasbeenreportedtoimmunoprecipitateRas. Immunocytochemistry: 2.5μg/mLofthisantibodyhasbeenreportedtoshowpositiveimmunostainingforRasinSW480andY1cells. Immunohistochemistry: ThisantibodyhasbeenreportedtodetectRasinfrozenandparaffinembeddedbreastcarcinomasections. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedrecombinantRas.CloneRAS10. |
| Clone | RAS10 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Thisantibodyrecognizesp21H-,K-andN-Ras. |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Proventoreactwithhuman,mouseandrat.Otherspeciesunknown. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | MembersoftheRASsuperfamilyofGTP-bindingproteins,whichincludesMRAS,aremembrane-anchored,intracellularsignaltransducersresponsIBLeforavarietyofnormalcellularfunctions.Theyareoncogenicallyactivatedinasignificantfractionoftumors.[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity. Enzymeregulation:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP). SIZE:189aminoacids;21,656Da SUBUNIT:InteractswithPHLPP(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside. Involvementindisease: DefectsinKRASareacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment. DefectsinKRASareacauseofjuvenilemyelomonocyticleukemia(JMML)[MIM:607785].JMMLisapediatricmyelodysplasticsyndromethatconstitutesapproximately30%ofchildhoodcasesofmyelodysplasticsyndrome(MDS)and2%ofleukemia.ItischaracterizedbyleukocytosiswithtissueinfiltrationandinvitrohypersensitivityofmyeloidProgenitorstogranulocyte-macrophagecolonystimulatingfactor. DefectsinKRASarethecauseofNoonansyndrome3(NS3)[MIM:609942].Noonansyndrome(NS)[MIM:163950]isadisordercharacterizedbydysmorphicfacialfeatures,shortstature,hypertelorism,cardiacanomalies,deafness,motordelay,andableedingdiathesis.Itisageneticallyheterogeneousandrelativelycommonsyndrome,withanestimatedincidenceof1in1000-2500livebirths.Rarely,NSisassociatedwithjuvenilemyelomonocyticleukemia(JMML).NS3inheritanceisautosomaldominant. DefectsinKRASareacauseofcardiofaciocutaneoussyndrome(CFCsyndrome)[MIM:115150];alsoknownascardio-facio-cutaneoussyndrome.CFCsyndromeischaracterizedbyadistinctivefacialappearance,heartdefectsandmentalretardation.Heartdefectsincludepulmonicstenosis,atrialseptaldefectsandhypertrophiccardiomyopathy.Someaffectedindividualspresentwithectodermalabnormalitiessuchassparse,friablehair,hyperkeratoticskinlesionsandageneralizedichthyosis-likecondition.TypicalfacialfeaturesaresimilartoNoonansyndrome.Theyincludehighforeheadwithbitemporalconstriction,hypoplasticsupraorbitalridges,downslantingpalpebralfissures,adepressednasalbridge,andposteriorlyangulatedearswithprominenthelices.TheinheritanceofCFCsyndromeisautosomaldominant. KRASmutationsareinvolvedincancerdevelopment. |
| MolecularWeight | 21kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
