密理博/04-1039 |抗Ras/p21抗体，克隆EP1125Y，兔单克隆/04-1039/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-1039 |
| Description | Anti-Ras/p21Antibody,cloneEP1125Y,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Ras,aproto-oncogene,isasmallG-proteinthathas3primaryisoforms(H-Ras,N-Ras,andK-Ras)thatdifferintheirapproximately20C-terminalaminoacids.H-RaswasfirstdiscoveredasatransformingproducttheretrovirusHarveymurinevirusandK-RasofKirtensarcomavirus.Rasisaheavilystudiedtargetofbothacademicandpharmaceuticalresearchbecauseofitsimplicationsinvariouspathwaysanddiseasesaswellasbeingmutatedinalargenumberofhumancancers.RasismostnotablytheactivatoroftheErk/MAPKkinasepathwayasactivatorofRaf,aswellasanactivatorofPI3Kinase(PI3K).Initsoncogenic,mutatedstate,RasisunabletohydrolyzeGTPtoGDP,thusstayinginanactivestateandactivatingnumerouspathwaysincludingtheMAPKpathwaythroughitsactivationofRaf,butalsoothersaswellthatincludePI3KinaseandRalGDS. |
| ProductInformation | |
|---|---|
| Format | Unpurified |
| Control |
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| Presentation | RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoresiduesneartheN-terminalregionofhumanRas. |
| Epitope | N-terminus |
| Clone | EP1125Y |
| Host | Rabbit |
| Specificity | ThisantibodydetectsH-Ras,N-RasandK-RasatandaroundtheN-terminus. |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisisanN-rasoncogeneencodingamembraneproteinthatshuttlesbetweentheGolgiapparatusandtheplasmamembrane.ThisshuttlingisregulatedthroughpalmitoylationanddepalmitoylationbytheZDHHC9-GOLGA7complex.Theencodedprotein,whichhasintrinsicGTPaseactivity,isactivatedtoaGTP-boundformbyaGTPaseactivatingproteinandinactivatedtoaGDP-boundformbyaguaninenucleotide-exchangefactor.Defectsinthisgeneareacauseofjuvenilemyelomonocyticleukemia(JMML). |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:InhibitoryregulatoroftheRas-cyclicAMPpathway.StimulatestheGTPaseofnormalbutnotoncogenicRasp21. SUBUNITSTRUCTURE:InteractswithSQTSM1.InteractswithSPSB1.InteractionwithSPSB1doesnotpromotedegradation. SUBCELLULARLOCATION:Cytoplasm. PTM:TheN-terminusisblocked. INVOLVEMENTINDISEASE:MutationsintheSH2domainofRASAseemtobeoncogenicandcausebasalcellcarcinomas. DefectsinRASA1arethecauseofcapillarymalformation-arteriovenousmalformation(CMAVM)[MIM:608354].CMAVMisadisordercharacterizedbyatypicalcapillarymalformationsthataremultiple,small,roundtoovalinshapeandpinkishredincolor.Thesecapillarymalformationsareassociatedwitheitherarteriovenousmalformation,arteriovenousfistula,orParkesWebersyndrome. DefectsinRASA1areacauseofParkesWebersyndrome(PKWS)[MIM:608355].PKWSisadisordercharacterizedbyacutaneousflushwithunderlyingmultiplemicro-arteriovenousfistulas,inassociationwithsofttissueandskeletalhypertrophyoftheaffectedlimb. SEQUENCESIMILARITIES:Contains1C2domain. Contains1PHdomain. Contains1Ras-GAPdomain. Contains2SH2domains. Contains1SH3domain. |
| MolecularWeight | ~21kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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