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Millipore/14-865 | p53-GST (recombinant protein)/14-865/50 µg

Millipore/14-865 | p53-GST (recombinant protein)/14-865/50 µg
市场价:
¥9240.00
美元价:
5544.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 14-865 |
BrandFamily | Upstate |
TradeName |
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Description | p53-GST(recombinantprotein) |
Overview | N-terminalGST-tagged,recombinantfulllengthhumanP53protein,expressedinE.coli.Purifiedusingglutathioneagarosechromatography. |
AlternateNames |
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ProductInformation | |
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Presentation | Recombinantproteininbuffercontaining20mMTris-HCl,pH8.0,100mMKCl,5mMglutathione,0.5mMEDTA,0.5mMDTT,1mMPMSFcontaining20%glycerol. |
StorageandShippingInformation | |
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StorageConditions | 1yearat-20°C |
Applications | |
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KeyApplications |
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BIOLOGicalInformation | |
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Concentration | 0.5mg/mL |
Purity | ~95%bySDS-PAGE |
Source | Full-lengthhumanp53protein,expressedine.coli. |
SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodestumorproteinp53,whichrespondstodiversecellularstressestoregulatetargetgenesthatinducecellcyclearrest,apoptosis,senescence,DNArepair,orchangesinmetabolism.p53proteinisexpressedatlowlevelinnormalcellsandatahighlevelinavarietyoftransformedcelllines,whereit"sbelievedtocontributetotransformationandmalignancy.p53isaDNA-bindingproteincontainingtranscriptionactivation,DNA-binding,andoligomerizationdomains.Itispostulatedtobindtoap53-bindingsiteandactivateexpressionofdownstreamgenesthatinhibitgrowthand/orinvasion,andthusfunctionasatumorsuppressor.Mutantsofp53thatfrequentlyoccurinanumberofdifferenthumancancersfailtobindtheconsensusDNAbindingsite,andhencecausethelossoftumorsuppressoractivity.Alterationsofthisgeneoccurnotonlyassomaticmutationsinhumanmalignancies,butalsoasgermlinemutationsinsomecancer-pronefamilieswithLi-Fraumenisyndrome.Multiplep53variantsduetoalternativepromotersandmultiplealternativesplicinghavebeenfound.Thesevariantsencodedistinctisoforms,whichcanregulatep53transcriptionalactivity.[providedbyRefSeq] |
GeneSymbol |
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PurificationMethod | Glutathioneagarosechromatography |
UniProtNumber | |
MolecularWeight | 72kDa |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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