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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
商品详细Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
商品编号: MAB4709
品牌: 密理博
市场价: ¥6360.00
美元价: 3816.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMAB4709
Replaces04-443
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-Caspase9Antibody,clone2-23
AlternateNames
  • ICE-LAP6
  • Mch-6
  • Apaf-3
ProductInformation
FormatPurified
PresentationPurifiedimmunoglobulinbyproteinA.LiquidinPBS,pH7.6,with0.1%sodiumazide.
StorageandShippingInformation
StorageConditionsMaintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months.
Applications
ApplicationAnti-Caspase9Antibody,clone2-23isanantibodyagainstCaspase9foruseinIP,WB,IH(P).
KeyApplications
  • Immunoprecipitation
  • WesternBlotting
  • Immunohistochemistry(Paraffin)
ApplicationNotesWesternblot:1:1000Immunohistochemistry(frozenandparaffin):1:500-1:1000

Optimalworkingdilutionsmustbedeterminedbyenduser.
BIOLOGicalInformation
ImmunogenRecombinanthumancaspase-9prodomain
Clone2-23
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityRecognizes46-48kDafull-lengthprocaspase-9,humanrecombinantcaspase-9andprocaspase-9fromhumancelllysates.Highlyspecifictocaspase-9andshowsnocross-reactionwithothercaspasefamilymembers.Activationofprocaspase-9byApaf-1inthecytochromecpathwayrequiresproteolyticcleavagetogenerateactivecaspase-9.Onceactivated,capsase-9initiatesacaspasecascadeinvolvingthedownstreamexecutionercaspases3,6and7.
IsotypeIgG1
SpeciesReactivity
  • Human
  • Mouse
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneencodesamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.ThisproteinisprocessedbycaspaseAPAF1;thisstepisthoughttobeoneoftheearliestinthecaspaseactivationcascade.Alternativesplicingresultsintwotranscriptvariantswhichencodedifferentisoforms.
GeneSymbol
  • CASP9
  • CASP-9
  • ICE-LAP6
  • MCH6
  • APAF3
  • CASPASE-9c
  • OTTHUMP00000044594
  • APAF-3
  • EC3.4.22.62[Contains:Caspase-9subunitp35
  • Caspase-9subunitp10].
Non-ReactiveSpecies
  • Rat
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P55211#Isoform2lacksactivityisandominant-negativeinhibitorofcaspase-9.
SIZE:416aminoacids;46281Da
SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya35kDa(p35)anda10kDa(p10)subunit.Caspase-9andAPAF1bindtoeachotherviatheirrespectiveNH2-terminalCED-3homologousdomainsinthepresenceofcytochromeCandATP.InteractswiththeinhibitorsBIRC2,BIRC4,BIRC5andBIRC7.
TISSUESPECIFICITY:Ubiquitous,withhighestexpressionintheheart,moderateexpressioninliver,skeletalmuscle,andpancreas.Lowlevelsinallothertissues.
PTM:CleavagesatAsp-315bygranzymeBandatAsp-330bycaspase-3generatethetwoactivesubunits.Caspase-8and-10canalsobeinvolvedintheseprocessingevents.
SIMILARITY:SwissProt:P55211##BelongstothepeptidaseC14family.&Contains1CARDdomain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。