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Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
Millipore/MAB4709 | Anti-Caspase 9 Antibody, clone 2-23/MAB4709/100 µg
市场价:
¥6360.00
美元价:
3816.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB4709 |
| Replaces | 04-443 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Caspase9Antibody,clone2-23 |
| AlternateNames |
|
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedimmunoglobulinbyproteinA.LiquidinPBS,pH7.6,with0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Recombinanthumancaspase-9prodomain |
| Clone | 2-23 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Recognizes46-48kDafull-lengthprocaspase-9,humanrecombinantcaspase-9andprocaspase-9fromhumancelllysates.Highlyspecifictocaspase-9andshowsnocross-reactionwithothercaspasefamilymembers.Activationofprocaspase-9byApaf-1inthecytochromecpathwayrequiresproteolyticcleavagetogenerateactivecaspase-9.Onceactivated,capsase-9initiatesacaspasecascadeinvolvingthedownstreamexecutionercaspases3,6and7. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.ThisproteinisprocessedbycaspaseAPAF1;thisstepisthoughttobeoneoftheearliestinthecaspaseactivationcascade.Alternativesplicingresultsintwotranscriptvariantswhichencodedifferentisoforms. |
| GeneSymbol |
|
| Non-ReactiveSpecies |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55211#Isoform2lacksactivityisandominant-negativeinhibitorofcaspase-9. SIZE:416aminoacids;46281Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya35kDa(p35)anda10kDa(p10)subunit.Caspase-9andAPAF1bindtoeachotherviatheirrespectiveNH2-terminalCED-3homologousdomainsinthepresenceofcytochromeCandATP.InteractswiththeinhibitorsBIRC2,BIRC4,BIRC5andBIRC7. TISSUESPECIFICITY:Ubiquitous,withhighestexpressionintheheart,moderateexpressioninliver,skeletalmuscle,andpancreas.Lowlevelsinallothertissues. PTM:CleavagesatAsp-315bygranzymeBandatAsp-330bycaspase-3generatethetwoactivesubunits.Caspase-8and-10canalsobeinvolvedintheseprocessingevents. SIMILARITY:SwissProt:P55211##BelongstothepeptidaseC14family.&Contains1CARDdomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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