Millipore/AB3612 |抗半胱天冬酶12抗体，前体蛋白，aa 100-116/AB3612/100µ；G
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB3612 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Caspase12Antibody,prodomain,aa100-116 |
| BackgroundInformation | Threedistinctsignalingpathwaysleadtoapoptosis.Thedeathreceptorandmitochondrionarethetwomainpathwayswhichinvolvecaspase-8andcaspase-9,respectively.Theendoplasmicreticulumstressisthethirdapoptoticpathwayandinvolvescaspase-12.LocalizedtotheERbutnottocytoplasmormitochondria,caspase-12isactivatedbyERstress,includingdisruptionofERcalciumhomeostasis.Caspase-12isco-localizedtotheERwithseveralproteinsthatareinvolvedinAlzheimer"sdiseaseincludingγ-secretasepresenilinandß-amyloidprecursorprotein(APP).Caspase-12mediatesERstress-inducedapoptosisaswellascytotoxicityinducedbyamyloid-ß.Caspase-12isubiquitouslyexpressedinmousetissues. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | ImmunoaffinitychromatographypurifiedantibodysuppliedinPBScontaining0.02%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2°-8°Cforuptooneyearfromdateofreceipt |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidecorrespondingtoaminoacids100-116ofmurinecaspase-12. |
| Epitope | prodomain,aa100-116 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Antibodyrecognizescaspase-12pro-proteininmouseextractsofnormalandapoptoticcells.Caspase-12ispredictedtohavealarge,>120aa,longprodomainregion.Thusthisantibodyrecognizesonlytheproformsoftheenzymeandnottheactivesubunits.Uncleaved(proform)caspase-12isprominentlydetectedinmanytissues.Activeformsaredifficulttodetectexpectintransfectcellsystems.{Kalai,Metal(2003)162:457-467}. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneSummary | CaspasesarecysteineproteasesthatcleaveC-terminalasparticacidresiduesontheirsubstratemolecules.Thisgene,CASP12,ismosthighlyrelatedtomembersoftheICEsubfamilyofcaspasesthatprocessinflammatorycytokines.Inrodents,thehomologofthisgenemediatesapoptosisinresponsetoendoplasmicreticulumstress.However,inhumansthisgenecontainsapolymorphismforthepresenceorabsenceofaprematurestopcodon.Themajorityofhumanindividualshavetheprematurestopcodonandproduceatruncatednon-functionalprotein.Theread-throughcodonoccursprimarilyinindividualsofAfricandescentandcarriershaveendotoxinhypo-responsivenessandanincreasedsusceptibilitytoseveresepsis. |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | SIZE:341aminoacids;38907Da |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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