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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/AB10512 | Anti-Caspase 6 (active form) Antibody/AB10512/100 µg
商品详细Millipore/AB10512 | Anti-Caspase 6 (active form) Antibody/AB10512/100 µg
Millipore/AB10512 | Anti-Caspase 6 (active form) Antibody/AB10512/100 µg
Millipore/AB10512 | Anti-Caspase 6 (active form) Antibody/AB10512/100 µg
商品编号: AB10512
品牌: 密理博
市场价: ¥6780.00
美元价: 4068.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB10512
Replaces04-1045
DescriptionAnti-Caspase6(activeform)Antibody
AlternateNames
  • ApoptoticproteaseMch-2
  • caspase6
  • caspase6,apoptosis-relatedcysteinepeptidase
  • caspase6,apoptosis-relatedcysteineprotease
BackgroundInformationCaspasesareafamilyofcytosolicaspartate-specificcysteineproteasesinvolvedintheinitiationandexecutionofapoptosis.Caspase6isamajorapoptoticexecutioner(1,2).Itexistsasapro-domainproteinandiscleavedbycaspase-3intotwosubunits,an18kDaanda10kDasubunitthatdimerizetoformtheactiveenzyme(3).Caspase6cleavesamongmanydifferentintracellularproteins,nuclearlamins.Laminsplayasignificantroleinmaintainingtheintegrityofthecellmembrane,andtheircleavageresultsinsubsequentcellularbreakdownanddeath(4).
ProductInformation
FormatAffinityPurified
Control
  • Ratkidneytissuelysate
PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationDetectCaspase6(activeform)usingthisAnti-Caspase6(activeform)AntibodyvalidatedforuseinWB,IH.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry
ApplicationNotesImmunohistochemistryAnalysis:1:600dilutionfromapreviouslotdetectedCaspase6incolorectalcarcinomatissue.
BIOLOGicalInformation
ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheC-terminusofthelargesubunitofratCaspase6.
EpitopeC-terminusofthelargesubunitofCaspase6
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostRabbit
SpecificityTheantibodyrecognizesthelargesubunitofactiveCaspase6.
SpeciesReactivity
  • Rat
  • Human
  • Bovine
  • Feline
  • Chimpanzee
SpeciesReactivityNoteDemonstratedtoreactwithhumanandrat.Predictedtoreactwithbovine,feline,andchimpanzeebasedon100%sequencehomology.
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryMemberofthecysteine-asparticacidprotease(caspase)familythatplaysaterminalroleinapoptosis[RGD].
GeneSymbol
  • CASP-6
  • MCH2
PurificationMethodAffinityPurfied
UniProtNumber
UniProtSummarySEQUENCESIMILARITIES:BelongstothepeptidaseC14Afamily.
MolecularWeight~18kDaObserved.UniProtKB/TrEMBLQ6AZ23listsaMWof31,574Daforthefulllengthproteinwhichisnormallycleavedintoalargeandsmallsubunit.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。