Millipore/06-735 | Anti-Caspase 3 Antibody/06-735/200 µg
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-735 |
| Replaces | 04-1090;04-439 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Caspase3Antibody |
| BackgroundInformation | Caspase-3/Yama/Apopain,alsoknownasproICEandCPP32,isamemberoftheICE-likeproteasefamily.Caspase-3isexpressedasa32kDaprecursor,whichisproteolyticallycleavedtoyieldanactiveformcomprisedof17kDaand12kDasubunits,respectively.Theactiveenzymeappearstoplayanimportantroleintheregulationorexecutionofapoptosis.Oneofitstargetsubstratesistheenzymepoly(ADP-ribose)polymerase(PARP)whichisinvolvedinDNArepairandmaintenanceofgenomeintegrity. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ProteinApurifiedIgGinof0.1MTris-glycine,pH7.4,0.15MNaCl,and0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor2yearsat2-8°Cfromdateofshipment.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | ThisAnti-Caspase3AntibodyisvalidatedforuseinWBforthedetectionofCaspase3. |
| KeyApplications |
|
| ApplicationNotes | Suggesteddilutions: WesternBlot:1μg/mL |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Humanfull-lengthCaspase3fusionproteincontainingahistidine-6tag |
| Host | Rabbit |
| Specificity | Recognizesfull-lengthCaspase3(Yama/Apopain)andproteolyticfragments. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteincleavesandactivatescaspases6,7and9,andtheproteinitselfisprocessedbycaspases8,9and10.Itisthepredominantcaspaseinvolvedinthecleavageofamyloid-beta4Aprecursorprotein,whichisassociatedwithneuronaldeathinAlzheimer"sdisease.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodethesameprotein. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P42574#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Attheonsetofapoptosisitproteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs)betweenthebasichelix-loop-helixleucinezipperdomainandthemembraneattachmentdomain.Cleavesandactivatescaspase-6,-7and-9.Involvedinthecleavageofhuntingtin. SIZE:277aminoacids;31608Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya17kDa(p17)anda12kDa(p12)subunit. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinlung,spleen,heart,liverandkidney.Moderatelevelsinbrainandskeletalmuscle,andlowintestis.Alsofoundinmanycelllines,highestexpressionincellsoftheimmunesystem. PTM:CleavagebygranzymeB,caspase-6,caspase-8andcaspase-10generatesthetwoactivesubunits.Additionalprocessingofthepropeptidesislikelyduetotheautocatalyticactivityoftheactivatedprotease.Activeheterodimersbetweenthesmallsubunitofcaspase-7proteaseandthelargesubunitofcaspase-3alsooccurandviceversa. SIMILARITY:SwissProt:P42574##BelongstothepeptidaseC14family. |
| MolecularWeight | 32kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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