Millipore/06-503 | Anti-Caspase 1 Antibody/06-503/200 µg
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-503 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Caspase1Antibody |
| AlternateNames |
|
| BackgroundInformation | Caspase-1,alsoknownasIL-1beta-convertingenzyme(ICE),isanezymethatcleavestheinflammatorycytokinesIL-1betaandIL-18,releasingthemature,activepeptides.Caspase-1isimportantfordefenseagainstpathogensanditalsoisinvolvedintheinductionofapoptosis.Thymocytesfromcaspase-1deficientmiceareresistanttoFas-mediatedapoptosis,andcaspase-1issimilartothecelldeathgeneCED-3ofC.elegans.Caspase-1isaheterotetramerthatconsistsoftwoanti-parallelheterodimers,eachoneformedbya20kDa(p20)anda10kDa(p10)subunit.TheenzymehasapreferredcleavagesiteofTyr-Val-Ala-Asp(YVAD).Caspase-1ishighlyexpressedinspleenandlung,andisabsentfrombrain. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaClcontaining0.05%sodiumazide.Frozensolution. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations: Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerol-containingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacidresidues129-149ofhumanCaspase1(PEHKTSDSTFLVFMSHGIREG). |
| Epitope | a.a.129-149 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Recognizesthep45proenzyme,Mr45kDa,andthep20subunit,Mr20kDa,ofreducedhumanCaspase1isoforms. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse,Rat.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproduce2subunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisgenewasidentifiedbyitsabilitytoproteolyticallycleaveandactivatetheinactiveprecursorofinterleukin-1,acytokineinvolvedintheprocessessuchasinflammation,septicshock,andwoundhealing.Thisgenehasbeenshowntoinducecellapoptosisandmayfunctioninvariousdevelopmentalstages.StudiesofasimilargeneinmousesuggestaroleinthepathogenesisofHuntingtondisease.Alternativesplicingofthisgeneresultsinfivetranscriptvariantsencodingdistinctisoforms. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P29466#ThiolproteasethatcleavesIL-1betabetweenanAspandanAla,releasingthematurecytokinewhichisinvolvedinavarietyofinflammatoryprocesses.Importantfordefenseagainstpathogens.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Canalsopromoteapoptosis. SIZE:404aminoacids;45159Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda10kDa(p10)subunit.Thep20subunitcanalsoformaheterodimerwiththeepsilonisoformwhichthenhasaninhibitoryeffect.Maybeacomponentoftheinflammasome,aproteincomplexwhichalsoincludesPYCARD,CARD8andNALP2andwhosefunctionwouldbetheactivationofproinflammatorycaspases. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Expressedinlargeramountsinspleenandlung.Detectedinliver,heart,smallintestine,colon,thymus,prostate,skeletalmuscle,peripheralbloodleukocytes,kidneyandtestis.Noexpressioninthebrain. PTM:Thetwosubunitsarederivedfromtheprecursorsequencebyanautocatalyticmechanism. SIMILARITY:SwissProt:P29466##BelongstothepeptidaseC14family.&Contains1CARDdomain....hide»seemore» |
| MolecularWeight | Proenzyme(45kDa)andp20subunit(20kDa) |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
