Millipore/04-571 |抗半胱天冬酶2抗体，兔单克隆/04-571/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-571 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Caspase2Antibody,rabbitmonoclonal |
| BackgroundInformation | Caspase-2(Nedd2/ICH-1)ispartofafamilyofaspartate-specificcysteineproteasesthatparticipateinprogrammedcelldeath,orapoptosis.Caspase-2islocalizedtothenucleus,andhasbeenshowntoplayrolesinbothpositiveandnegativeregulationofapoptosis(1).Uponapoptoticstimulation,pro-caspase-9iscleavedinaseriesofstepstoproducean18-kDalargesubunitanda12-kDasmallfragment(2).Caspase-2canbeanuclearinitiatorcaspase,asithasbeenshowntoprecedetheprocessingandactivationofcaspase-8,-9,and-3(3).Caspase-2mightalsoactasaneffectorcaspase;inapoptoticpathwaysresultingfromUV-inducedDNAdamage,processingofcaspase-2occursdownstreamofcaspase-9andcaspase-3activation(4). |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Buffer:50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Storeat-20°C.Stablefor12monthsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | AsyntheticpeptidecorrespondingtoN-terminusofhumanCaspase-2p15subunit.Theantibodyshouldrecognizebothpro-form(~50kDa)andp15cleaved-formofCaspase-2. |
| Clone | Y61 |
| Host | Rabbit |
| Specificity | RecognizesHuman,MouseCaspase-2. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse(positivecontrol:Jurkatcelllysate) |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theproteolyticcleavageofthisproteinisinducedbyavarietyofapoptoticstimuli.Alternativesplicingofthisgeneresultsinmultipletranscriptvariantsthatencodedifferentisoforms. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P42575#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Mightfunctionbyeitheractivatingsomeproteinsrequiredforcelldeathorinactivatingproteinsnecessaryforcellsurvival. SIZE:452aminoacids;50685Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbyap18subunitandap12subunit.InteractswithLRDD. TISSUESPECIFICITY:Expressedinlargeramountsintheembryoniclung,liverandkidneythanintheheartandbrain.Intheadultshigherlevelexpressionisseenintheplacenta,lung,kidney,pancreasthanintheheart,brain,liverandskeletalmuscle. PTM:Thematureproteasecanprocessitsownpropeptide,butnotthatofothercaspases. SIMILARITY:SwissProt:P42575##BelongstothepeptidaseC14family.&Contains1CARDdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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