密理博/04-441 |抗Caspase-7抗体,兔单克隆/04-441/100µ;L
市场价:
¥0.00
美元价:
0.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-441 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Caspase-7Antibody,rabbitmonoclonal |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | In60%storagebuffer(50mMTris-Glycine(pH7.4),0.15MNaCl,0.01%sodiumazideand0.05%BSA)and40%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearat-20°Cfromdateofshipment.Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerol-containingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedsyntheticpeptidecomposedofresiduesattheN-terminusofhumanCaspase-7. |
| Host | Rabbit |
| Specificity | RecognizesaregioncomposedofresiduesattheN-terminusofhumanCaspase-7. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theprecursorofthiscaspaseiscleavedbycaspase3and10.Itisactivateduponcelldeathstimuliandinducesapoptosis.Alternativesplicingresultsinfourtranscriptvariants,encodingthreedistinctisoforms. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55210#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Proteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Overexpressionpromotesprogrammedcelldeath. SIZE:303aminoacids;34277Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda11kDa(p11)subunit. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinlung,skeletalmuscle,liver,kidney,spleenandheart,andmoderatelyintestis.Noexpressioninthebrain. PTM:CleavagesbygranzymeBorcaspase-10generatethetwoactivesubunits.Propeptidedomainscanalsobecleavedefficientlybycaspase-3.Activeheterodimersbetweenthesmallsubunitofcaspase-7andthelargesubunitofcaspase-3,andviceversa,alsooccur. SIMILARITY:SwissProt:P55210##BelongstothepeptidaseC14family. |
| MolecularWeight | 34kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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