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当前位置: 首页 > 产品中心 > Functional_antibody > 密理博/04-441 |抗Caspase-7抗体,兔单克隆/04-441/100µ;L
商品详细密理博/04-441 |抗Caspase-7抗体,兔单克隆/04-441/100µ;L
密理博/04-441 |抗Caspase-7抗体,兔单克隆/04-441/100µ;L
密理博/04-441 |抗Caspase-7抗体,兔单克隆/04-441/100µ;L
商品编号: 04-441
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber04-441
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionAnti-Caspase-7Antibody,rabbitmonoclonal
ProductInformation
FormatPurified
PresentationIn60%storagebuffer(50mMTris-Glycine(pH7.4),0.15MNaCl,0.01%sodiumazideand0.05%BSA)and40%glycerol.
StorageandShippingInformation
StorageConditions2yearat-20°Cfromdateofshipment.Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerol-containingsolutionstobecomefrozenduringstorage.
Applications
ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectCaspase-7usingthisAnti-Caspase-7Antibody,RabbitvalidatedforuseinIF,IP,WB,IH(P).
KeyApplications
  • Immunofluorescence
  • Immunoprecipitation
  • WesternBlotting
  • Immunohistochemistry(Paraffin)
BIOLOGicalInformation
ImmunogenKLH-conjugatedsyntheticpeptidecomposedofresiduesattheN-terminusofhumanCaspase-7.
HostRabbit
SpecificityRecognizesaregioncomposedofresiduesattheN-terminusofhumanCaspase-7.
IsotypeIgG
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theprecursorofthiscaspaseiscleavedbycaspase3and10.Itisactivateduponcelldeathstimuliandinducesapoptosis.Alternativesplicingresultsinfourtranscriptvariants,encodingthreedistinctisoforms.
GeneSymbol
  • CASP7
  • CASP-7
  • ICE-LAP3
  • CMH-1
  • MCH3
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P55210#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Proteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Overexpressionpromotesprogrammedcelldeath.
SIZE:303aminoacids;34277Da
SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda11kDa(p11)subunit.
SUBCELLULARLOCATION:Cytoplasm.
TISSUESPECIFICITY:Highlyexpressedinlung,skeletalmuscle,liver,kidney,spleenandheart,andmoderatelyintestis.Noexpressioninthebrain.
PTM:CleavagesbygranzymeBorcaspase-10generatethetwoactivesubunits.Propeptidedomainscanalsobecleavedefficientlybycaspase-3.Activeheterodimersbetweenthesmallsubunitofcaspase-7andthelargesubunitofcaspase-3,andviceversa,alsooccur.
SIMILARITY:SwissProt:P55210##BelongstothepeptidaseC14family.
MolecularWeight34kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。