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Millipore/04-1045 | Anti-Caspase-6 (Pro) Antibody, clone EP1325Y, rabbit monoclonal/04-1045/100 µL
Millipore/04-1045 | Anti-Caspase-6 (Pro) Antibody, clone EP1325Y, rabbit monoclonal/04-1045/100 µL
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-1045 |
| Description | Anti-Caspase-6(Pro)Antibody,cloneEP1325Y,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Caspasesareafamilyofcytosolicaspartate-specificcysteineproteasesinvolvedintheinitiationandexecutionofapoptosis.Caspase-6isamajorapoptoticexecutioner(1,2).Itexistsasapro-domainproteinandiscleavedbycaspase-3intotwoactivesubunits,an18kDaanda10kDasubunit(3).Caspase-6cleavesamongmanydifferentintracellularproteins,nuclearlamins.Laminsplayasignificantroleinmaintainingtheintegrityofthecellmembrane,andtheircleavageresultsinsubsequentcellularbreakdownanddeath(4). |
| ProductInformation | |
|---|---|
| Format | Unpurified |
| Control |
|
| Presentation | RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidecorrespondingtoresiduesofhumanpro-Caspase-6. |
| Clone | EP1325Y |
| Host | Rabbit |
| Specificity | Thisantibodyrecognizespro-Caspase6. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Proventoreactinhuman. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteinisprocessedbycaspases7,8and10,andisthoughttofunctionasadownstreamenzymeinthecaspaseactivationcascade.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodedifferentisoforms.[providedbyRefSeq]. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavespoly(ADP-ribose)polymeraseinvitro,aswellaslamins.Overexpressionpromotesprogrammedcelldeath. CATALYTICACTIVITY:StrictrequirementforAspatpositionP1andhasapreferredcleavagesequenceofVal-Glu-His-Asp-|-. ENZYMEREGULATION:ActivationissuppressedbyphosphorylationatSer-257.Ref.5 SUBUNITSTRUCTURE:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya18kDa(p18)anda11kDa(p11)subunit. SUBCELLULARLOCATION:Cytoplasm. PTM:Cleavagesbycaspase-3,caspase-8or-10generatethetwoactivesubunits. SEQUENCESIMILARITY:BelongstothepeptidaseC14Afamily. |
| MolecularWeight | ~35kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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