Millipore/MAB302 |抗谷氨酰胺合成酶抗体，克隆GS-6/MAB302/100µ；G
市场价：
¥9660.00
美元价：
5796.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB302 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GlutamineSynthetaseAntibody,cloneGS-6 |
| BackgroundInformation | GlutamineSynthetasecatalyzestheconversionofammoniaandglutamatetoglutamine.Itisfoundinastrocytesasanoctamerofidentical45kDasubunits.ThefunctionofGlutamineSynthetaseisthedetoxificationofbrainammonia.Italsohasanimportantroleinthemetabolicregulationofneurotransmitterglutamate.BecauseofthemultiplefunctionsandimportanceofGlutamineSynthetaseincellularmetabolism,bothcatalyticactivitiesandsynthesisarehighlyregulated.TheactivityofGlutamineSynthetaseiscontrolledbyadenylylation.ItsactivityisdecreasedinthecerebralcortexofbrainsaffectedbyAlzheimer"sdisease,particularlyinthevicinityofsenileplaques.Itisalsodecreasedunderconditionsofglucosedeprivation.ThelevelofexpressionofGlutamineSynthetaseisincreasedduringischemiainvivoorhypoxiainculture. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedimmunoglobulin.Liquidinbuffercontaining50%glycerol,BSAand0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainantibodyat2–8°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze-thawcycles. |
| Applications | |
|---|---|
| Application | DetectGlutamineSynthetaseusingthisAnti-GlutamineSynthetaseAntibody,cloneGS-6validatedforuseinELISA,IH,IH(P)&WBwithmorethan45productcitations. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:1:1,000-1:5,000 Immunohistochemistryonratbrain ELISA Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Glutaminesynthetasepurifiedfromsheepbrain. |
| Clone | GS-6 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ReactsstronglywithasinglebandonWesternblotsofsheepbrainandratbrain.Glutaminesynthetase,anenzymethatcatalyzestheaminationofglutamicacidtoformglutamine,isfoundinmammalsasanoctamerofeightidentical45kDasubunits.GlutaminesynthetaseactivityhasbeenshowntobeausefulMarkerofastrocytesandanimportantdifferentiationfeatureinretina.Glutaminesynthetaseisalsoconsideredtobeakeyenzymeintherecyclingoftheneurotransmitterglutamate. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glutamineisamainsourceofenergyandisinvolvedincellproliferation,inhibitionofapoptosis,andcellsignaling(Haberleetal.,2005[PubMed16267323]).Fetalglutaminerequirementsareveryhighanddependlargelyonactiveglutaminesynthesisandthereleaseofglutamineintothefetalcirculationbytheplacenta.Glutaminesynthetase(EC6.3.1.2),alsocalledglutamate-ammonialigase(GLUL),isexpressedthroughoutthebodyandplaysanimportantroleincontrollingbodypHandinremovingammoniafromthecirculation.TheenzymeclearsL-glutamate,themajorneurotransmitterinthecentralnervoussystem,fromneuronalsynapses(seereferencesinClancyetal.,1996[PubMed8975719]).[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P15104#CatalyzestheconversionofammoniaandL-glutamatetoL-glutamine. SIZE:373aminoacids;42064Da SUBUNIT:Homooctamer. SUBCELLULARLOCATION:Cytoplasm. DISEASE:SwissProt:P15104#DefectsinGLULarethecauseofcongenitalsystemicglutaminedeficiency(CSGD)[MIM:610015].CSGDisararedevelopmentaldisorderwithseverebrainmalformationresultinginmulti-organfailureandneonataldeath.Glutamineislargelyabsentfromaffectedpatientsserum,urineandcerebrospinalfluid. SIMILARITY:SwissProt:P15104##Belongstotheglutaminesynthetasefamily. |
| MolecularWeight | 45kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
