Millipore/AB1783 |抗谷氨酸转运体抗体，胶质细胞/AB1783/50µ；L
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1783 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GlutamateTransporterAntibody,Glial |
| AlternateNames |
|
| BackgroundInformation | Glutamatetransporters(GluT)functiontoremoveL-glutamate(Glu),theprimaryexcitatoryneurotransmitterinthemammaliancentralnervoussystem(CNS),fromthesynapticcleft.ByclearingthesynapseinthismannerGlucanberecycledforlateruse,theproperdiffusiongrADIentcanbemaintainedandexcitotoxicitycanbeprevented.TherehavebeenreportsofmanydifferentmembersofaGluTmultigenefamily;GLT1,GLAST,EAAC1andEAAT2.mRNAhasbeenidentifiedinbrainforeachoftheseproteins. EAAT2transportsL-glutamateandalsoL-andD-aspartate.Itisessentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Guineapigantiserumcontainingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidefromthecarboxy-terminusofratGLT-1. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | GuineaPig |
| Specificity | GlialGlutamateTransporterGLT-1(EAAT2).Theantibodyhasbeentestedoncentralnervoussystemtissue.Preabsorptionoftheantiserumwiththeimmunogenpeptide(CatalognumberAG391)completelyabolishestheimmunostaining. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofafamilyofsolutetransporterproteins.Themembrane-boundproteinistheprincipaltransporterthatclearstheexcitatoryneurotransmitterglutamatefromtheextracellularspaceatsynapsesinthecentralnervoussystem.Glutamateclearanceisnecessaryforpropersynapticactivationandtopreventneuronaldamagefromexcessiveactivationofglutamatereceptors.Mutationsinanddecreasedexpressionofthisproteinareassociatedwithamyotrophiclateralsclerosis.Alternativelysplicedtranscriptvariantsofthisgenehavebeendescribed,buttheirfull-lengthnatureisnotknown. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P43004#TransportsL-glutamateandalsoL-andD-aspartate.Essentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium. SIZE:574aminoacids;62104Da SUBUNIT:Homotrimer. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. PTM:Glycosylated. SIMILARITY:SwissProt:P43004##Belongstothesodium:dicarboxylate(SDF)symporter(TC2.A.23)family. |
| MolecularWeight | ~62kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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