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Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg
Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5406 |
| Replaces | AB5992;AB5862P |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GAD67Antibody,clone1G10.2 |
| AlternateNames |
|
| BackgroundInformation | Gutamicaciddecarboxylase(GAD;E.C.4.1.1.15)istheenzymeresponsIBLefortheconversionofglutamicacidtogamma-aminobutyricacid(GABA),themajorinhibitorytransmitterinhigherbrainregions,andputativeparacrinehormoneinpancreaticislets.TwomolecularformsofGAD(65kDaand67kDa,64%aaidentitybetweenforms)arehighlyconservedandbothformsareexpressedintheCNS,pancreaticisletcells,testis,oviductandovary.Theisoformsareregionallydistributedcytoplasmicallyinthebrainsofratsandmice(Sheikh,1999).GAD65isanamphiphilic,membrane-anchoredprotein(585a.a.),encodedonhumanchromosome10,andisresponsibleforvesicularGABAproduction.GAD67iscytoplasmic(594a.a.),encodedonchromosome2,andseemstoberesponsibleforsignificantcytoplasmicGABAproduction.GADexpressionchangesduringneuraldevelopmentinratspinalcord.GAD65isexpressedtransientlyincommissuralaxonsaroundE13butisdownregulatedthenextdaywhileGAD67expressionincreasesmostlyinthesomataofthoseneurons(Phelps,1999).Inmatureratpancreas,GAD65andGAD67appeartobedifferentiallylocalized,GAD65primarilyininsulin-containingbetacellsandGAD67inglucagon-containing(A)cells(Li,1995).GAD67expressionseemstobeparticularlyplasticandcanchangeinresponsetoexperimentalmanipulation(forexampleneuronalstimulationortransection)ordiseaseprogressionandemergentdisorderslikeschizophrenia(Volk,2000).ColocalizationofthetwoGADisoformsalsoshowschangesinGAD65/GAD67distributionscorrelatedwithcertaindiseasestatessuchasIDDMandSMS. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2ainbuffercontaining0.1%sodiumazide |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8ºCinundilutedaliquotsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantGAD67protein |
| Clone | 1G10.2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Reactswiththe67kDaisoformofGlutamateDecarboxylase(GAD67)ofrat,mouseandhumanorigins,otherspeciesnotyettested.NodetectablecrossreactivitywithGAD65byWesternblotonratbrainlysatewhencomparedtoblotprobedwithAB1511thatreactswithbothGAD65&GAD67. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesoneofseveralformsofglutamicaciddecarboxylase,identifiedasamajorautoantigenininsulin-dependentdiabetes.Theenzymeencodedisresponsibleforcatalyzingtheproductionofgamma-aminobutyricacidfromL-glutamicacid.ApathogenicroleforthisenzymehasbeenidentifiedinthehumanpancreassinceithasbeenidentifiedasanautoantigenandanautoreactiveTcelltargetininsulin-dependentdiabetes.Thisgenemayalsoplayaroleinthestiffmansyndrome.Deficiencyinthisenzymehasbeenshowntoleadtopyridoxinedependencywithseizures.Alternativesplicingofthisgeneresultsintwoproducts,thepredominant67-kDformandaless-frequent25-kDform. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q99259#CatalyzestheproductionofGABA. COFACTOR:Pyridoxalphosphate. SIZE:594aminoacids;66897Da SUBUNIT:Homodimer. TISSUESPECIFICITY:GAD67isexpressedintheCNS,pancreaticisletcells,testis,oviductandovary. DISEASE:SwissProt:Q99259#DefectsinGAD1arethecauseofautosomalrecessivesymmetricspasticcerebralpalsy(SCP)[MIM:603513].Cerebralpalsy(CP)isanheterogeneousgroupofneurologicaldisordersofmovementand/orposture,withanestimatedincidenceof1in250to1"000livebirths,makingCPonethecommonestcongenitaldisABIlities.Non-progressiveformsofsymmetrical,spasticCPhavebeenidentified,whichshowaMendelianautosomalrecessivepatternofinheritance.Patientspresentdevelopmentaldelay,mentalretardationandsometimesepilepsyaspartofthephenotype. SIMILARITY:SwissProt:Q99259##BelongstothegroupIIdecarboxylasefamily. |
| MolecularWeight | 67kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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