微孔/AB9206 |抗DARPP-32抗体，磷酸化THR34/AB9206/100µ；L
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB9206 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-DARPP-32Antibody,phosphoThr34 |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | AffinityPurifiedimmunoglobulin.Liquidin10mMHEPES,pH7.5,150mMNaCl,100μgpermLBSAwith50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefromDARPP-32,phosphoThr34. |
| Epitope | phosphoThr34 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesDARPP-32phosphorylatedatthreonine34. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Midbraindopaminergicneuronsplayacriticalroleinmultiplebrainfunctions,andabnormalsignalingthroughdopaminergicpathwayshasbeenimplicatedinseveralmajorneurologicandpsychiatricdisorders.Onewell-studiedtargetfortheactionsofdopamineisDARPP32.Inthedenselydopamine-andglutamate-innervatedratcaudate-putamen,DARPP32isexpressedinmedium-sizedspinyneurons(OuimetandGreengard,1990[PubMed2191086])thatalsoexpressdopamineD1receptors(WalaasandGreengard,1984[PubMed6319627]).ThefunctionofDARPP32seemstoberegulatedbyreceptorstimulation.Bothdopaminergicandglutamatergic(NMDA)receptorstimulationregulatetheextentofDARPP32phosphorylation,butinoppositedirections(Halpainetal.,1990[PubMed2153935]).DopamineD1receptorstimulationenhancescAMPformation,resultinginthephosphorylationofDARPP32(WalaasandGreengard,1984[PubMed6319627]);phosphorylatedDARPP32isapotentproteinphosphatase-1(seeMIM176875)inhibitor(Hemmingsetal.,1984[PubMed6087160]).NMDAreceptorstimulationelevatesintracellularcalcium,whichleadstoactivationofcalcineurinanddephosphorylationofphospho-DARPP32,therebyreducingthephosphatase-1inhibitoryactivityofDARPP32(Halpainetal.,1990[PubMed2153935]).[suppliedbyOMIM] |
| GeneSymbol |
|
| Modifications |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9UD71#Inhibitorofprotein-phosphatase1. SIZE:204aminoacids;22963Da SUBCELLULARLOCATION:Cytoplasm. PTM:Dopamine-andcyclicAMP-regulatedneuronalphosphoprotein.&PhosphorylationofThr-34isrequiredforactivity(Bysimilarity). SIMILARITY:SwissProt:Q9UD71##Belongstotheproteinphosphataseinhibitor1family. |
| MolecularWeight | ~32kD |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
