密理博/AB1594P |抗5-羟色胺转运体抗体/AB1594P/50µ；G
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1594P |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-SEROtoninTransporterAntibody |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Affinitypurifiedimmunoglobulin.Liquidin100mMTris,pH7.5with0.2%BSAand0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | Anti-SerotoninTransporterAntibodyisanantibodyagainstSerotoninTransporterforuseinELISA&WB. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:1-10μg/mL CellpelletsareresUSPendedin100μLlysisbuffer(25mMTris,pH7.6,150mMNaCl,1μg/mLaprotonin,10μg/mLleupeptin,1mMphenylmethylsulfonylfluoride,1mMsodiumorthovanadate,1mMEDTA,and1%TritonX-100).Sampleswereincubatedfor1hourat4°Candwerepelletedathighspeedfor10minutesat4°C,and100μgproteinpersamplewassubjectedto10%sodiumdodecylsulfate-polyacrylamidegelelectrophoresis. ELISA:1:100,000primaryEIAusingimmunogenonly(50-100ngSERTpeptide(CatalogNumberAG297)/well).Nottestedonpurifiedproteinatthestateddilutions. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | A15aminoacidsequencebetweentransmembranedomain7and8oftheratserotonintransporter.Thisregionispresumablyfromtheextracellulardomain. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | SerotoninTransporter(SERT).AnantibodyraisedagainstasimilarpeptidehasbeenshowntoreactwithaSERTinbaculoviruscellsexpressingrecombinantratandhumanSERT.AntibodyactivitymaybereducedconsiderablywhendetectingendogenousSERTfromratorhumancells.SERThasbeenobservedtomigrateas94kDa(ratplatelet),80kDa(pulmonarymembranes)and76kDa(ratbrain).Thiscouldbeduetodifferencesinpostranslationalmembranemodifications(e.g.glycosylation). |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesanintegralmembraneproteinthattransportstheneurotransmitterserotoninfromsynapticspacesintopresynapticneurons.Theencodedproteinterminatestheactionofserotoninandrecyclesitinasodium-dependentmanner.Thisproteinisatargetofpsychomotorstimulants,suchasamphetaminesandcocaine,andisamemberofthesodium:neurotransmittersymporterfamily.Arepeatlengthpolymorphisminthepromoterofthisgenehasbeenshowntoaffecttherateofserotoninuptakeandmayplayaroleinsuddeninfantdeathsyndrome,aggressivebehaviorinAlzheimerdiseasepatients,anddepression-susceptibilityinpeopleexperiencingemotionaltrauma. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P31645#Terminatestheactionofserotoninbyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:630aminoacids;70325Da SUBUNIT:InteractswithTGFB1I1. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. SIMILARITY:SwissProt:P31645##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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