密理博/MAB5550 |抗TorsinA抗体/MAB5550/100µ；L
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5550 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-TorsinAAntibody |
| BackgroundInformation | TorsinAcanregulatethecellulartraffickingofthedopaminetransporter,aswellasotherpolytopicmembrane-boundproteins,includingGprotein-coupledreceptors,transporters,andionchannels.TorsinAisfoundinthedopamineneuronsthatarelostinPD,andisacomponentofLewybodies.inaddition,ageneticdefectinTorsinAunderliesTorsiondystonia,adiseasecharacterizedbypainfulmusclecontractionsthatresultinuncontrollabledistortions. |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | Liquid.Containgsnopreservative |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | ThisAnti-TorsinAAntibodyisvalidatedforuseinIP,WB,ICforthedetectionofTorsinA. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | MaltosebindingproteinfusionproteinfromhumantorsinA. |
| Host | Mouse |
| Specificity | TorsinA |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheAAAfamilyofadenosinetriphosphatases(ATPases),isrelatedtotheClpprotease/heatshockfamilyandisexpressedprominentlyinthesubstantianigraparscompacta.Mutationsinthisgeneresultintheautosomaldominantdisorder,torsiondystonia1. |
| GeneSymbol |
|
| PurificationMethod | Ascites |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:O14656#Mayserveasamolecularchaperoneassistingintheproperfoldingofsecretedand/ormembraneproteins. SIZE:332aminoacids;37809Da SUBUNIT:InteractswithTOR1AIP1andTOR1AIP2. SUBCELLULARLOCATION:Endoplasmicreticulumlumen.Nucleusmembrane.Note=Mainlylocatedinthelumenoftheendoplasmicreticulum.Alsofoundassociatedwiththenuclearenvelope.TheGlu-303delvariantislumenally-orientedindiscretelargespheroidintracellularstructuresratherthanintheendoplasmicreticulum. TISSUESPECIFICITY:Widelyexpressed.Highestlevelsinkidneyandliver.Notdetectedinspleen.Inthebrain,highlevelsfoundinthedopaminergicneuronsofthesubstantianigraparscompacta,aswellasintheneocortex,hippocampusandcerebellum.Alsohighexpressioninthespinalcord. DISEASE:SwissProt:O14656#DefectsinTOR1Aarethecauseoftorsiondystonia1(DYT1)[MIM:128100];alsoknownasprimaryoridiopathicdystonia.Thisautosomaldominantdisorderisthemostcommonandseveretypeofdystoniamanifestingitselfassustainedmusclecontractionsinducingtwistingandrepetitivemovementsand/orabnormalposture.Symptomsusuallybegininthearmsorlegsatameanageof12yearsandprogresstootherbodypartswithin5years. SIMILARITY:SwissProt:O14656##BelongstotheclpA/clpBfamily.Torsinsubfamily. |
| MolecularWeight | 37kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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