Millipore/MAB5280 |抗酪氨酸羟化酶抗体，克隆2/40/15/MAB5280/40µ；G
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5280 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-TyrosineHydroxylaseAntibody,clone2/40/15 |
| AlternateNames |
|
| BackgroundInformation | Tyrosinehydroxylaseplaysanimportantroleinthephysiologyofadrenergicneurons.Itisthefirstandrate-limitingenzymeinvolvedinthebiosynthesisofthecatecholaminesDopamineandNorepinephrinefromtyrosine.THis,therefore,ausefulMarkerfordopaminergicandnoradrenergicneurons.TheenzymaticactivityofTHrequiresferrousionsascofactorsandisbelievedtoberegulatedbyphosphorylation.AtleastfourisoformsofhumanTHhavebeenidentifiedwhichresultfromalternativesplicing. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2ainbuffercontaining0.02MPhosphatebuffer,0.25MNaCl,pH7.6with0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8ºCinundilutedaliquotsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Purifiedtyrosinehydroxylase(EC1.14.16.2)fromaratpheochromocytoma(2). |
| Clone | 2/40/15 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Tyrosinehydroxylase(TH)catalyzestherate-determininginitialstepinthebiosynthesisofcatecholaminessuchasdopamine,noradrenalineandadrenaline.Thereforetheantibodyisusedtostaindopaminergeousandadrenergeousneuronsaswellasthechromaffinetissueoftheadrenalmedulla.CelllinessuchasthePC12line,whichisderivedfromaratpheochromocytomaalso,showpositivereactions.Inimmunoblotsofadrenalmedullatissue,theantibodyrecognizesasingleproteinbandinthemolecularweightrangeof56-60kD. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| MolecularWeight | 56-60kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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