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Millipore/MAB5278 | Anti-Tryptophan Hydroxylase/Tyrosine Hydroxylase/Phenylalanine Hydroxylase Antibody, clone PH8/MAB52
Millipore/MAB5278 | Anti-Tryptophan Hydroxylase/Tyrosine Hydroxylase/Phenylalanine Hydroxylase Antibody, clone PH8/MAB52
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5278 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-TryptophanHydroxylase/TyrosineHydroxylase/PhenylalanineHydroxylaseAntibody,clonePH8 |
| BackgroundInformation | PH8AntibodyisamurinemonoclonalantibodythatbindsacommonepitopeofTryptophanhydroxylase(TRH),Tyrosinehydroxylase(TYH)andPhenylalaninehydroxylase(PAH).1IntheliteraturethismonoclonalantibodyiscitedasPH8.Tyrosinehydroxylase(TYH)istheenzymewhichconvertstyrosinetodihydroxyphenylalanine(L-dopa),aprecursorofthecatecholamineneurotransmittersdopamine,noradrenalineandadrenaline.Tryptophanhydroxylase(TRH)istheenzymethatconverts5-hydroxytryptophantoSEROtonin.InfreshtissuethePH8AntibodybindstoTYHandTRHsoisaMarkerforTYH-containingcatecholaminergicneurons,2andserotonergicneurons.3,4,5Tryptophanhydroxylase(TRH)canbeusedasamarkerforserotoninasitconverts5-hydroxy-tryptophantoserotonin.Serotoninisrapidlymetabolisedandisunabletobedetectedbyanti-serotoninantibodiesinpostmortemtissue.Inhumantissuethathasbeenformalin-fixed,duetoachangeintheantigenicdeterminantoftyrosinehydroxylase(TYH),PH8Antibodywillbindonlytryptophanhydroxylase(TRH).3,4,5ThePH8Antibodycanthereforebeusedtospecificallyidentifyserotonergicneuronsinfixedhumantissue.Phenylalaninehydroxylase(PAH)canbedetectedinhepatictissuesectionsusingthePH8Antibody. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | TheimmunoglobulinfractionhasbeenpurifiedfromascitesfluidbyProteinGchromatography.500μgliquidproteinat2mg/mLinphosphatebufferedsaline(PBS).Theproductissuppliedsterile-filteredthrougha0.22micronfilter. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | ThePH8Antibodyisshippedliquidatambienttemperature.Liquidmaterialisstableforatupto6monthswhenstoredat2-8°C. |
| BIOLOGicalInformation | |
|---|---|
| Clone | PH8 |
| Host | Mouse |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthepterin-dependentaromaticacidhydroxylasefamily.Theencodedproteincatalyzesthefirstandratelimitingstepinthebiosynthesisofserotonin,animportanthormoneandneurotransmitter.Thehumangenomecontainstworelatedtryptophanhydroxylases,oneonchromosome11p15-p14andoneonchromosome12q21.Thisgeneisexpressedpredominantlyinthegut,pinealgland,spleen,andthymus. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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