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Millipore/MAB308 | Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2/MAB308/100 µL
Millipore/MAB308 | Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2/MAB308/100 µL
市场价：
¥6360.00
美元价：
3816.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB308 |
| Replaces | MAB394-250UG;MAB394-100UG;MAB394-25UG |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-DopamineβHydroxylaseAntibody,clone4F10.2 |
| AlternateNames |
|
| BackgroundInformation | DopamineBetaHydroxylase(DBH),thestructurallocusencodingDβHenzyme,isamajorquantitativetraitlocusinfluencingplasmaDβHactivity,withonesinglenucleotidepolymorphism(SNP)accountingforupto50%ofthevariance.MutationsatDBHappeartoberesponsIBLefortheraresyndromeofDβHdeficiency.Itfunctionsastheonlyenzymeinvolvedinthesynthesisofsmall-moleculeneurotransmittersthatismembrane-bound,makingnorepinephrineandepinephrinetheonlytransmitterssynthesizedinsidevesicles.Itisexpressedinnoradrenergicnerveterminalsofthecentralandperipheralnervoussystems,aswellasinchromaffincellsoftheadrenalmedulla. |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | AscitesmousemonoclonalIgG1inliquidwith0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedbovineDBH. |
| Clone | 4F10.2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Dopaminebetahydroxylase(DBH). |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisanoxidoreductasebelongingtothecoppertypeII,ascorbate-dependentmonooxygenasefamily.Itispresentinthesynapticvesiclesofpostganglionicsympatheticneuronsandconvertsdopaminetonorepinephrine.Itexistsinbothsolubleandmembrane-boundforms,dependingontheabsenceorpresence,respectively,ofasignalpeptide. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P09172#Conversionofdopaminetonoradrenaline. COFACTOR:Binds1PQQpersubunit.&Binds2copperionspersubunit. SIZE:617aminoacids;69065Da SUBUNIT:Homotetramercomposedoftwonon-covalentlybounddisulfide-linkeddimers. SUBCELLULARLOCATION:Solubledopaminebeta-hydroxylase:Cytoplasmicvesicle,secretoryvesiclelumen.Cytoplasmicvesicle,secretoryvesicle,chromaffingranulelumen.&Cytoplasmicvesicle,secretoryvesiclemembrane;Single-passtypeIImembraneprotein.Cytoplasmicvesicle,secretoryvesicle,chromaffingranulemembrane;Single-passtypeIImembraneprotein(Potential). DISEASE:SwissProt:P09172#DefectsinDBHarethecauseofDBHdeficiency[MIM:223360];alsocallednorepinephrinedeficiencyornoradrenalinedeficiency.Thisdisorderischaracterizedbyprofounddeficitsinautonomicandcardiovascularfunction,butapparentlyonlysubtlesigns,ifany,ofcentralnervoussystemdysfunction. SIMILARITY:SwissProt:P09172##BelongstothecoppertypeIIascorbate-dependentmonooxygenasefamily.&Contains1DOMONdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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